Copyright
©2006 Baishideng Publishing Group Co.
World J Gastroenterol. Sep 7, 2006; 12(33): 5336-5343
Published online Sep 7, 2006. doi: 10.3748/wjg.v12.i33.5336
Published online Sep 7, 2006. doi: 10.3748/wjg.v12.i33.5336
Table 1 Characteristics of gallstone patients (GS) and healthy controls
Characteristics | GS (n = 10) | Controls (n = 10) | P |
Gender | |||
Male | 4 | 4 | |
Female | 6 | 6 | |
Age (yr) | |||
Mean ± SE | 49.5 ± 2.3 | 50.5 ± 1.4 | NS |
Range | 30-63 | 28-61 | |
BMI (kg/m2 ) | |||
Mean ± SE | 23.0 ± 0.8 | 22.8 ± 0.4 | NS |
Range | 21-28 | 20-29 | |
Biliary colic | 10/10 | 0/10 | |
Gallstones | |||
n (single/multiple) | 3/7 | ||
Size (< 1.5 cm) | 10/10 |
Table 2 Baseline biochemical parameters in gallstone patients (GS) and controls (mean ± SD)
Biochemical parameter | GS (n = 10) | Controls (n = 10) | P |
Serum creatinine (mg/dL) | 0.98 ± 0.25 | 0.96 ± 0.21 | NS |
Blood nitrogen (mg/dL) | 39.4 ± 13.0 | 37.7 ± 10.6 | NS |
AST (IU/I) | 23.2 ± 15.0 | 21.3 ± 12.7 | NS |
ALT (IU/I) | 23.9 ± 14.6 | 21.8 ± 11.6 | NS |
AP (IU/I) | 147.3 ± 63.2 | 150 ± 60.5 | NS |
γGT (IU/I) | 28.0 ± 18.0 | 30.2 ± 15.8 | NS |
Total proteins (g/dL) | 6.8 ± 0.57 | 6.9 ± 0.58 | NS |
Total cholesterol (mg/dL) | 185.0 ± 38.5 | 178.4 ± 35 | NS |
Fasting triglycerides (mg/dL) | 141.7 ± 30.8 | 138.5 ± 27.2 | NS |
Fasting glucose (mg/dL) | 96.8 ± 12.0 | 95.3 ± 11.4 | NS |
Table 3 Fasting and residual gallbladder volumes, and percent gallbladder emptying before and after ursodeoxycholic acid (UDCA) and placebo administration in gallstone patients (n = 10) and healthy controls (n = 10)
Basal | UDCA | Placebo | P2 | |
Fasting Volume (mL): | ||||
Controls | 18.8 (0.9) | 22.9 (0.6) | 19.1 (0.9) | 0.001 |
Gallstones | 23.5 (0.9) | 26.2 (0.5) | 24.1 (0.9) | |
P1 | 0.0001 | |||
Residual Volume (mL): | ||||
Controls | 4.7 (0.8) | 6.4 (0.7) | 4.9 (0.7) | 0.003 |
Gallstones | 8.5 (0.3) | 11.0 (1.0) | 8.5 (0.2) | |
P1 | 0.0001 | |||
Gallbladder emptying (%) | ||||
Controls | 76 (2.3) | 71.9 (3.2) | 74.5 (2.2) | 0.066 |
Gallstones | 63.8 (2.4) | 59.5 (3.3) | 61.6 (2.2) | |
P1 | 0.001 |
Table 4 Relationship between serum bile acids and intestinal transit time (OITT), gastric half emptying time (t½ min ) and gallbladder emptying (%) in gallstone patients (n = 10) and healthy controls (n = 10) (univariate analysis)
OITT(min) | Gastric emptying(t½, min) | Gallbladder emptying(%) | ||||
r | P | r | P | r | P | |
CA | -0.696 | 0.001 | -0.118 | 0.62 | 0.44 | 0.05 |
DCA | 0.887 | 0.0001 | 0.503 | 0.024 | -0.617 | 0.004 |
CDCA | -0.728 | 0.0001 | -0.547 | 0.012 | 0.594 | 0.006 |
- Citation: Colecchia A, Mazzella G, Sandri L, Azzaroli F, Magliuolo M, Simoni P, Bacchi-Reggiani M, Roda E, Festi D. Ursodeoxycholic acid improves gastrointestinal motility defects in gallstone patients. World J Gastroenterol 2006; 12(33): 5336-5343
- URL: https://www.wjgnet.com/1007-9327/full/v12/i33/5336.htm
- DOI: https://dx.doi.org/10.3748/wjg.v12.i33.5336