Relationship between somatostatin receptor subtype expression and clinicopathology, Ki-67, Bcl-2 and p53 in colorectal cancer

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 12, Issue 13

This Article

Citation of this article

Corresponding Author of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

All Articles published online

Item

Count

PDF

373

HTML

2248

Tables (1-3)

124

Sum=2745

Apr 7, 2006 (publication date) through Apr 27, 2024

Times Cited of This Article

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Colorectal Cancer

World J Gastroenterol. Apr 7, 2006; 12(13): 2011-2015
Published online Apr 7, 2006. doi: 10.3748/wjg.v12.i13.2011

Table 1 SSTR expression in colorectal cancer

^aP< 0.05 vs normal mucosa.

Table 2 Correlation between SSTR expression and clinicopathology in colorectal cancer n (%)

Clinico-pathological factor		n	SSTR1	SSTR2	SSTR3	SSTR4	SSTR5
Sex	Male	73	47(64.4)	26(35.6)	13(17.8)	13(17.8)	28(38.4)
Sex	Female	54	35(64.8)	20(37.0)	11(20.4)	11(20.4)	21(38.9)
Age (yr)	< 60	66	45(68.2)	20(30.3)	12(18.2)	12(18.2)	24(36.4)
Age (yr)	≥ 60	61	37(60.7)	26(42.6)	12(19.7)	12(19.7)	25(41.0)
Tumor site	Right colon	31	18(58.1)	11(35.5)	7(22.6)	6(19.4)	11(35.5)
	Left colon	27	17(63.0)	12(44.4)	5(18.5)	6(22.2)	13(48.1)
	Rectum	69	47(68.1)	23(33.3)	12(17.4)	12(17.4)	25(36.2)
Macroscopic type	Elevated	40	27(67.5)	17(42.5)	10(25.0)	9(22.5)	17(42.5)
	Ulcerative	59	37(62.7)	13(22.0)a	8(13.6)	8(13.6)	21(35.6)
	Infiltrative	28	18(64.3)	16(57.1)	6(21.4)	7(25.0)	11(39.3)
Differentiation	Moderate to well	102	70(68.6)	43(42.2)a	22(21.6)	24(23.5)a	46(45.1)a
Differentiation	Poor	25	12(48.0)	3(12.0)	2(8.0)	0(0.0)	3(12.0)
Tumor depth	Muscularis	24	14(58.3)	11(45.8)	5(20.8)	3(12.5)	9(37.5)
Tumor depth	Serosa	103	68(66.0)	35(34.0)	19(18.4)	21(20.4)	40(38.8)
Lymph node metastasis	(+)	72	52(72.2)a	24(33.3)	12(16.7)	15(20.8)	26(36.1)
Lymph node metastasis	(-)	55	30(54.5)	22(40.0)	12(21.8)	9(16.4)	23(41.8)
Distant metastasis	(+)	20	15(75.0)	6(30.0)	3(15.0)	2(10.0)	7(35.0)
Distant metastasis	(-)	107	67(62.6)	40(37.4)	21(19.6)	22(20.6)	42(39.3)
Dukes’ stage	A	13	7(53.8)	5(38.5)	4(30.8)	2(15.4)	6(46.2)
	B	40	22(55.0)	16(40.0)	8(20.0)	7(17.5)	16(40.0)
	C	54	38(70.4)	19(35.2)	9(16.7)	13(24.1)	20(37.0)

^aP < 0.05.

Table 3 Correlation between SSTR expression and proliferative index, Bcl-2 or p53 expression

		n	Ki67 proliferationIndexmean±SD	Expression ofBcl-2positive (%)	Expression ofp53positive (%)
SSTR1	(+)	82	34.22 ± 24.33	37(45.1)	53(64.6)
SSTR1	(-)	45	40.21 ± 22.97	30(66.7)^a	28(62.2)
SSTR2	(+)	46	28.65 ± 18.80	15(32.6)	33(71.7)
SSTR2	(-)	81	40.71 ± 25.50^a	52(64.2)^a	48(51.3)
SSTR3	(+)	24	25.72 ± 17.88	5(20.8)	17(70.8)
SSTR3	(-)	103	38.82 ± 24.55^a	62(60.2)^a	64(62.1)
SSTR4	(+)	24	28.02 ± 20.12	9(37.5)	16(66.7)
SSTR4	(-)	103	38.29 ± 24.42	58(56.3)	65(63.1)
SSTR5	(+)	49	32.20 ± 21.92	17(34.7)	34(69.4)
SSTR5	(-)	78	38.95 ± 24.91	50(64.1)^a	47(60.3)

^aP < 0.05.

Citation: Qiu CZ, Wang C, Huang ZX, Zhu SZ, Wu YY, Qiu JL. Relationship between somatostatin receptor subtype expression and clinicopathology, Ki-67, Bcl-2 and p53 in colorectal cancer. World J Gastroenterol 2006; 12(13): 2011-2015
URL: https://www.wjgnet.com/1007-9327/full/v12/i13/2011.htm
DOI: https://dx.doi.org/10.3748/wjg.v12.i13.2011