Relationship between somatostatin receptor subtype expression and clinicopathology, Ki-67, Bcl-2 and p53 in colorectal cancer

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Apr 7, 2006 (publication date) through Dec 22, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Colorectal Cancer

World J Gastroenterol. Apr 7, 2006; 12(13): 2011-2015
Published online Apr 7, 2006. doi: 10.3748/wjg.v12.i13.2011

Table 1 SSTR expression in colorectal cancer

^aP< 0.05 vs normal mucosa.

Table 2 Correlation between SSTR expression and clinicopathology in colorectal cancer n (%)

Clinico-pathological factor		n	SSTR1	SSTR2	SSTR3	SSTR4	SSTR5
Sex	Male	73	47(64.4)	26(35.6)	13(17.8)	13(17.8)	28(38.4)
Sex	Female	54	35(64.8)	20(37.0)	11(20.4)	11(20.4)	21(38.9)
Age (yr)	< 60	66	45(68.2)	20(30.3)	12(18.2)	12(18.2)	24(36.4)
Age (yr)	≥ 60	61	37(60.7)	26(42.6)	12(19.7)	12(19.7)	25(41.0)
Tumor site	Right colon	31	18(58.1)	11(35.5)	7(22.6)	6(19.4)	11(35.5)
	Left colon	27	17(63.0)	12(44.4)	5(18.5)	6(22.2)	13(48.1)
	Rectum	69	47(68.1)	23(33.3)	12(17.4)	12(17.4)	25(36.2)
Macroscopic type	Elevated	40	27(67.5)	17(42.5)	10(25.0)	9(22.5)	17(42.5)
	Ulcerative	59	37(62.7)	13(22.0)a	8(13.6)	8(13.6)	21(35.6)
	Infiltrative	28	18(64.3)	16(57.1)	6(21.4)	7(25.0)	11(39.3)
Differentiation	Moderate to well	102	70(68.6)	43(42.2)a	22(21.6)	24(23.5)a	46(45.1)a
Differentiation	Poor	25	12(48.0)	3(12.0)	2(8.0)	0(0.0)	3(12.0)
Tumor depth	Muscularis	24	14(58.3)	11(45.8)	5(20.8)	3(12.5)	9(37.5)
Tumor depth	Serosa	103	68(66.0)	35(34.0)	19(18.4)	21(20.4)	40(38.8)
Lymph node metastasis	(+)	72	52(72.2)a	24(33.3)	12(16.7)	15(20.8)	26(36.1)
Lymph node metastasis	(-)	55	30(54.5)	22(40.0)	12(21.8)	9(16.4)	23(41.8)
Distant metastasis	(+)	20	15(75.0)	6(30.0)	3(15.0)	2(10.0)	7(35.0)
Distant metastasis	(-)	107	67(62.6)	40(37.4)	21(19.6)	22(20.6)	42(39.3)
Dukes’ stage	A	13	7(53.8)	5(38.5)	4(30.8)	2(15.4)	6(46.2)
	B	40	22(55.0)	16(40.0)	8(20.0)	7(17.5)	16(40.0)
	C	54	38(70.4)	19(35.2)	9(16.7)	13(24.1)	20(37.0)

^aP < 0.05.

Table 3 Correlation between SSTR expression and proliferative index, Bcl-2 or p53 expression

		n	Ki67 proliferationIndexmean±SD	Expression ofBcl-2positive (%)	Expression ofp53positive (%)
SSTR1	(+)	82	34.22 ± 24.33	37(45.1)	53(64.6)
SSTR1	(-)	45	40.21 ± 22.97	30(66.7)^a	28(62.2)
SSTR2	(+)	46	28.65 ± 18.80	15(32.6)	33(71.7)
SSTR2	(-)	81	40.71 ± 25.50^a	52(64.2)^a	48(51.3)
SSTR3	(+)	24	25.72 ± 17.88	5(20.8)	17(70.8)
SSTR3	(-)	103	38.82 ± 24.55^a	62(60.2)^a	64(62.1)
SSTR4	(+)	24	28.02 ± 20.12	9(37.5)	16(66.7)
SSTR4	(-)	103	38.29 ± 24.42	58(56.3)	65(63.1)
SSTR5	(+)	49	32.20 ± 21.92	17(34.7)	34(69.4)
SSTR5	(-)	78	38.95 ± 24.91	50(64.1)^a	47(60.3)

^aP < 0.05.

Citation: Qiu CZ, Wang C, Huang ZX, Zhu SZ, Wu YY, Qiu JL. Relationship between somatostatin receptor subtype expression and clinicopathology, Ki-67, Bcl-2 and p53 in colorectal cancer. World J Gastroenterol 2006; 12(13): 2011-2015
URL: https://www.wjgnet.com/1007-9327/full/v12/i13/2011.htm
DOI: https://dx.doi.org/10.3748/wjg.v12.i13.2011