Melanoma differentiation-associated gene-7, MDA-7/IL-24, selectively induces growth suppression, apoptosis in human hepatocellular carcinoma cell line HepG2 by replication-incompetent adenovirus vector

doi:10.3748/wjg.v12.i11.1774

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Mar 21, 2006 (publication date) through Dec 22, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Mar 21, 2006; 12(11): 1774-1779
Published online Mar 21, 2006. doi: 10.3748/wjg.v12.i11.1774

Table 1 Over-expression of mda-7 induces apoptosis selectively in HCC cells

	L02			HepG2
	Control	Ad.vec	Ad.mda-7	Control	Ad.vec	Ad.mda-7
Early apoptotic cells	110 ± 23	120 ± 36	100 ± 11	50 ± 37^b	300 ± 85^d	1 990 ± 430
Late apoptotic cells	60 ± 14	100 ± 21	130 ± 15	10 ± 40^b	200 ± 63^d	1 370 ± 902
Total cells	170 ± 28	220 ± 45	230 ± 16	60 ± 72^b	500 ± 150^d	3 360 ± 132

The table shows the apoptotic cells in 10 000 cells. The percentage of early apoptotic cells (stained with Annexin-V only) and late apoptotic and necrotic cells (stained with PI) was calculated using the CellQuest software (Becton Dickinson, San Jose, CA, USA). ^bP < 0.01 vs Ad.mda-7 group; ^dP < 0.01 vs Ad.mda-7 group.

Citation: Wang CJ, Xue XB, Yi JL, Chen K, Zheng JW, Wang J, Zeng JP, Xu RH. Melanoma differentiation-associated gene-7, MDA-7/IL-24, selectively induces growth suppression, apoptosis in human hepatocellular carcinoma cell line HepG2 by replication-incompetent adenovirus vector. World J Gastroenterol 2006; 12(11): 1774-1779
URL: https://www.wjgnet.com/1007-9327/full/v12/i11/1774.htm
DOI: https://dx.doi.org/10.3748/wjg.v12.i11.1774