Role of bile acids, prostaglandins and COX inhibitors in chronic esophagitis in a mouse model

Table 1 Macroscopic and microscopic changes in mice esophageal mucosa (mean ±SE)

Model	Grades of acroscopic changes	Grades of microscopic changes	Grades of inflammation	Surface of esophagitis (% of all esophagus)	Ulcers of esophagus (mm2)
HCl	2.08 ± 0.11	2.63 ± 0.38	2.63 ± 0.24	15.50 ± 2.02	0 ± 0.0
HCl/P	3.69 ± 0.23 a	3.90 ± 0.10 a	3.90 ± 0.10 a	23.00 ± 2.31 a	7.09 ± 2.17 a
HCl/P/BA	2.58 ± 0.25c	2.64 ± 0.27 c	2.23 ± 0.26c	23.46 ± 3.85a	0.71 ± 0.49 ac
HCl/P/INDO	3.90 ± 0.08	3.92 ± 0.07	3.86 ± 0.11	25.12 ± 2.14	8.11 ± 2.31
HCl/P/NS-398	2.13 ± 0.21cg	2.12 ± 0.13 g	2.21 ± 0.11 cg	19.12 ± 1.34	5.12 ± 2.13
HCl/P/BA/INDO	3.92 ± 0.06 e	3.90 ± 0.10 e	3.93 ± 0.03 e	31.17 ± 2.45 e	1.35 ± 0.11e
HCl/P/BA/NS-398	2.32 ± 0.11 g	2.58 ± 0.14 g	2.42 ± 0.13 g	21.23 ± 1.21 g	0.98 ± 0.27

^aP<0.05 vs HCl;

^eP<0.05 vs HCl/P/BA;

^gP<0.05 INDO;

^cP<0.05 vs HCl/P.

Table 2 Concentration of pge2 in mouse esophagus

Model	1/3 upper part	1/3 middle part	1/3 lower part
HCl	801 ± 103	1027 ± 166a	378 ± 69 a
HCl/P	674 ± 107	766 ± 95c	405 ± 39
HCl/P/BA	807 ± 111 e	1264 ± 134 aceg	332 ± 59 a
HCl/P/INDO	500 ± 59	569 ± 60	388 ± 35
HCl/P/NS-398	576 ± 34	663 ± 59	324 ± 32
HCl/P/BA/INDO	553 ± 50	614 ± 64	324 ± 26
HCl/P/BA/NS-398	607± 50	733 ± 67	368 ± 43

Mean ± SE pg/mg of protein;

^aP<0.05 middle vs lower;

^e P<0.05 vs INDO;

^gP<0.05 vs NS-398;

^cP<0.05 HCl/P vs HCl/P/BA.