Effect of Hewei-Decoction on chronic atrophic gastritis and eradication of Helicobacter pylori

Table 1 Syndrome differentiation of CAG patients.

Syndrome types	Chief manifestations	n
PCAS	Sudden onset of gastric pain aggravated by pressure and alleviated by hot compression, preference for warmth and	12
	aversion to cold, absence of thirst, preference for hot drinks, white tongue coating, wiry and tense pulse
DHSS	Fullness or distending pain in the gastric area, bitter taste and stickiness in the mouth, heavy sensation in head and body,	14
	dyschesia, feverish sensation in the anus, red tip of the tongue with yellow and greasy coating, wiry and smooth pulse
DLS	Distending pain in gastric area radiating to hypochondriac area, fullness in chest, belching, sighing, vomiting,	36
	restlessness, irritability, insomnia, dyschesia, or diarrhea or constipation, pale tongue with thin and yellow coating, wiry pulse
QDSS	Fullness in gastric area, worse after meals; anorexia, lassitude, loose stools, pale and swollen tongue	16
	with thin and white coating, deep and weak pulse
YDSS	Continuous dull pain in gastric area relieved by warmth, pressure and intake of food; vomiting of clear fluid,	8
	anorexia, lassitude, cold limbs, loose stool, pale and swollen tongue with thin and white coating, thready and weak pulse
YDS	Dull burning pain in gastric area, restlessness and thirsty, dry mouth and throat, dry stools, dizziness, insomnia, poor	4
	appetite, feverish sensation in palms and soles, red tongue with little coating or peeling cracks on the tongue, thready and rapid pulse

PCAS: pathogenic cold attacking the stomach; DHSS: damp heat in the spleen and stomach; DLS: disharmony between the liver and spleen; QDSS: qi deficiency in the spleen and stomach; YDSS: yang deficiency in the spleen and stomach; YDS: yin deficiency in the stomach.

Table 2 Grade quantifications of chief symptoms and signs.

Symptoms	1	2	3
Gastric fullness	Slight	Endurable	Unendurable
Dull gastric pain	Slight	Endurable	Unendurable
Pricking gastric pain	Slight or none	Endurable	Severe and fixed
Dryness in mouth	Occasionally	In morning	On whole day
Bitter taste	Occasionally	In morning	On whole day
Tastelessness	Occasionally	From time to time	Frequently
Nausea	Frequently	Occasionally	From time to time
Stickiness in mouth	Occasionally	From time to time	Frequently
Acid regurgitation	Occasionally	From time to time	Frequently
Loose stools	Occasionally	Frequently	Severe
Dyschesia	Slight	Moderate	Severe
Dry stools	Occasionally	Frequently	Severe
Black stools	Occasionally	Moderate	Severe
Anorexia	Reduction of food ≤1/4	Reduction of food ≤1/3	Reduction of food ≤1/2
Fullness in chest	Slight	Sometimes	Severe
Lassitude	Slight	Hard to deal with daily tasks	Unable to deal with daily tasks
Short breath	After physical exercises	After mild physical exercises	Even in calm status
Yellow urine	Occasionally	Frequently, with scanty urine	Dark yellow severe and scanty urine

Table 3 Effect assessment of composite accumulation of reduced scores.

Syndrome types	HE	OE	E	NE	Total efficacy (%)
CAS	7	2	2	1	91.67
DHSS	7	3	3	1	92.86
DLS	28	6	1	1	97.22
QDSS	10	2	2	2	87.5
YDSS	1	2	3	2	75
YDS	1	2	0	1	75

HE: highly efficacious, OE: obviously efficacious, E: efficacious, NE: no effect.

Table 4 Relationship between efficacy and H pylori infection.

	Results of treatment		Total
	Effective	Ineffective
H pylori positive before treatment	54	2	56
H pylori negative before treatment	28	6	34
Total	82	8	90

g = 1, χ^² = 5.175, ^aP<0.05 vs Hpylori negative.

Table 5 Relationship between efficacy and H pylori eradication.

	Results of treatment		Total
	Effective	Ineffective
H pylori eradicated after treatment	37	1	38
H pylori non-eradicated after treatment	13	5	18
Total	50	6	56

g = 1, χ^² = 8.074, ^bP<0.01 vs Hpylori non-eradicated.