Helicobacter Pylori
Copyright ©2005 Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 21, 2005; 11(7): 986-989
Published online Feb 21, 2005. doi: 10.3748/wjg.v11.i7.986
Effect of Hewei-Decoction on chronic atrophic gastritis and eradication of Helicobacter pylori
Wan-Sheng Ji, Zhi-Xing Gao, Kai-Chun Wu, Jun-Wen Qiu, Bing-Long Shi, Dai-Ming Fan
Wan-Sheng Ji, Zhi-Xing Gao, Department of Internal Medicine, Weifang Medical College, Weifang 261042, Shandong Province, China
Kai-Chun Wu, Jun-Wen Qiu, Dai-Ming Fan, Institute of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, Shaanxi Province, China
Bing-Long Shi, Department of Digestive Diseases, Integral Hospital of Guangzhou Military Command, Guangzhou 510000, Guangdong Province, China
Author contributions: All authors contributed equally to the work.
Correspondence to: Dr. Wan-Sheng Ji, Department of Internal Medicine, Weifang Medical College, Weifang 261042, Shandong Province, China. jiwsh@wfmc.edu.cn
Telephone: +86-536-2992375
Received: April 4, 2004
Revised: April 6, 2004
Accepted: May 24, 2004
Published online: February 21, 2005
Abstract

AIM: To demonstrate the effect of Hewei-Decoction (Decoction for regulating the stomach) on chronic atrophic gastritis (CAG) and eradication of Helicobacter pylori.

METHODS: Ninety patients with CAG entering the investigation were divided into six differentiation syndromes, based on their major symptoms and signs. Hewei-Decoction was taken by all the patients orally for 4 or 8 wk. The efficacy was assessed by both the composite accumulation of reduced scores of major symptoms and the eradication of H pylori. χ2 test was used to compare the efficacy between H pylori-positive and negative cases, and to disclose the relationship between efficacy and eradication of H pylori.

RESULTS: In patients with six different syndrome types, the efficacy of Hewei-Decoction was 91.67% (11/12), 92.86% (13/14), 97.22% (35/36), 87.50% (14/16), 75.00% (6/8), 75.00% (3/4) respectively. The rate of highly efficacious was 58.33% (7/12), 50.00% (7/14), 77.78% (28/36), 62.50% (10/16), 12.50% (1/8) and 25.00% (1/4), respectively. The total efficacy was 91.11% (82/90), and the rate of highly efficacious was 60.00% (54/90). The eradication rate of H pylori was 67.86% (38/56). The therapeutic effect of Hewei-Decoction was better in H pylori positive cases than that in H pylori-negative cases with the total effect of 96.43% vs 82.35% (P<0.05). In 56 H pylori positive cases, the therapeutic effect was better in H pylori eradicated cases than that in H pylori- existent cases with the total effect of 97.37% vs 72.22% (P<0.01).

CONCLUSION: Hewei-Decoction is effective in most cases of all the syndrome types. The results indicate that eradication of H pylori is one of the important mechanisms for alleviation of symptoms and signs. Also, the decoction is efficacious in H pylori-negative cases.

Keywords: Chronic atrophic gastritis; Helicobacter pylori infection; Hewei-Decoction