Anti-Helicobacter pylori therapy significantly reduces Helicobacter pylori -induced gastric mucosal damage in Mongolian gerbils

Table 1 Comparison of gastric inflammation among H pylori-infected, H pylori-eradicated and H pylori-uninfected gerbils (mean±SE).

	Hp-infected Group A (n: 7)	Hp-eradicated Group B (n: 6)	Hp-uninfected Group C (n: 7)	P value
Stomach weight ratio (×1000)	14.1±0.3	9.8±0.2	8.9±0.3	<0.05a
				<0.05c
Hyperplasia area (mm2)	62.8±6.3	0.9±0.6	0	<0.05a
				<0.05c
Erosion and ulcer area (mm2)	2.2±0.6	0.4±0.3	0	<0.05a
				<0.05c
Score of gastritis	6.9±0.1	2.0±0.5	0	<0.05a
				<0.05c
MPO activity (mmol H2O2/min/g tissue)	100.4±5.9	5.7±1.3	4.6±2.3	<0.05a
				<0.05c
PGE2 synthesis (pg/mg wet weight/min)	77.0±15.3	30.6±11.9	26.9±14.4	<0.05a
				<0.05c

Stomach weight ratio: Weight of stomach over weight of body.

^aP<0.05: H pylori-infected vs H pylori-eradicated;

^cP<0.05: H pylori-infected vs H pylori-uninfected P value less than 0.05 was considered statistically siE 8.