Anti-Helicobacter pylori therapy significantly reduces Helicobacter pylori -induced gastric mucosal damage in Mongolian gerbils

doi:10.3748/wjg.v11.i7.982

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Feb 21, 2005 (publication date) through Apr 28, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Helicobacter Pylori

World J Gastroenterol. Feb 21, 2005; 11(7): 982-985
Published online Feb 21, 2005. doi: 10.3748/wjg.v11.i7.982

Anti-Helicobacter pylori therapy significantly reduces Helicobacter pylori -induced gastric mucosal damage in Mongolian gerbils

Chun-Chao Chang, Sheng-Hsuan Chen, Gi-Shih Lien, Yuarn-Jang Lee, Horng-Yuan Lou, Ching-Ruey Hsieh, Chia-Lang Fang, Shiann Pan

Chun-Chao Chang, Sheng-Hsuan Chen, Gi-Shih Lien, Yuarn-Jang Lee, Horng-Yuan Lou, Ching-Ruey Hsieh, Chia-Lang Fang, Shiann Pan, Department of Internal Medicine, Division of Gastroenterology, Taipei Medical University Hospital, Digestive Disease Research Center, Taipei Medical University, Taipei, Taiwan, China

Author contributions: All authors contributed equally to the work.

Correspondence to: Dr. Chun-Chao Chang, Department of Internal Medicine, Taipei Medical University Hospital, No. 252, Wu-Hsing Street, Taipei 110, Taiwan, China. chunchao@tmu.edu.tw

Telephone: +886-2-27372181-3903 Fax: +886-2-27363051

Received: June 24, 2004
Revised: June 27, 2004
Accepted: July 27, 2004
Published online: February 21, 2005

Abstract

AIM: To investigate the effectiveness of 4 d’ anti-Helicobacter pylori therapy on the H pylori-infected Mongolian gerbils based on physiological and pathological changes.

METHODS: We used 6-wk-old male gerbils orally inoculated with H pylori (ATCC43504, 2x10⁸ CFU/mL). Seven weeks after H pylori inoculation, the animals of study group received 4 d’ anti-H pylori triple therapy (H pylori-eradicated group). Seven days later, all animals of the H pylori-eradicated and control groups (H pylori-infected & H pylori-uninfected groups) were sacrificed. We examined gastric mucosal lesions macroscopically, studied gastritis microscopically and determined the stomach weight ratio, myeloperoxidase (MPO) activity and prostaglandin (PG) E₂ level.

RESULTS: The results showed that both macroscopic and histological gastric damages were significantly less in H pylori-eradicated group than H pylori-infected group. Stomach weight ratio, MPO activity and PGE₂ levels were significantly higher in H pylori-infected group than those in the other two groups.

CONCLUSION: Four days’ anti-H pylori therapy was effective in the improvement of H pylori-induced gastric lesions in Mongolian gerbils.

Keywords: Helicobacter pylori, anti-H pylori therapy, Mongolian gerbils, Gastritis