Helicobacter Pylori
Copyright ©2005 Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 21, 2005; 11(7): 982-985
Published online Feb 21, 2005. doi: 10.3748/wjg.v11.i7.982
Anti-Helicobacter pylori therapy significantly reduces Helicobacter pylori -induced gastric mucosal damage in Mongolian gerbils
Chun-Chao Chang, Sheng-Hsuan Chen, Gi-Shih Lien, Yuarn-Jang Lee, Horng-Yuan Lou, Ching-Ruey Hsieh, Chia-Lang Fang, Shiann Pan
Chun-Chao Chang, Sheng-Hsuan Chen, Gi-Shih Lien, Yuarn-Jang Lee, Horng-Yuan Lou, Ching-Ruey Hsieh, Chia-Lang Fang, Shiann Pan, Department of Internal Medicine, Division of Gastroenterology, Taipei Medical University Hospital, Digestive Disease Research Center, Taipei Medical University, Taipei, Taiwan, China
Author contributions: All authors contributed equally to the work.
Correspondence to: Dr. Chun-Chao Chang, Department of Internal Medicine, Taipei Medical University Hospital, No. 252, Wu-Hsing Street, Taipei 110, Taiwan, China. chunchao@tmu.edu.tw
Telephone: +886-2-27372181-3903 Fax: +886-2-27363051
Received: June 24, 2004
Revised: June 27, 2004
Accepted: July 27, 2004
Published online: February 21, 2005
Abstract

AIM: To investigate the effectiveness of 4 d’ anti-Helicobacter pylori therapy on the H pylori-infected Mongolian gerbils based on physiological and pathological changes.

METHODS: We used 6-wk-old male gerbils orally inoculated with H pylori (ATCC43504, 2x108 CFU/mL). Seven weeks after H pylori inoculation, the animals of study group received 4 d’ anti-H pylori triple therapy (H pylori-eradicated group). Seven days later, all animals of the H pylori-eradicated and control groups (H pylori-infected & H pylori-uninfected groups) were sacrificed. We examined gastric mucosal lesions macroscopically, studied gastritis microscopically and determined the stomach weight ratio, myeloperoxidase (MPO) activity and prostaglandin (PG) E2 level.

RESULTS: The results showed that both macroscopic and histological gastric damages were significantly less in H pylori-eradicated group than H pylori-infected group. Stomach weight ratio, MPO activity and PGE2 levels were significantly higher in H pylori-infected group than those in the other two groups.

CONCLUSION: Four days’ anti-H pylori therapy was effective in the improvement of H pylori-induced gastric lesions in Mongolian gerbils.

Keywords: Helicobacter pylori; anti-H pylori therapy; Mongolian gerbils; Gastritis