Association of cyclin D1, p16 and retinoblastoma protein expressions with prognosis and metastasis of gallbladder carcinoma

Table 1 Positive expression rates of Rb, p16 and cyclin D1.

Disease	n	Rb		Cyclin D1		p16
		+	%	+	%	+	%
Gallbladder carcinoma	41	24	58.7	28	68.3	20	48.8
Adenoma	7	7	100	4	57.1	7	100
Cholecystitis	14	14	100	1	7.1	13	92.8

Table 2 Correlation between expression rates of Rb, p16 and cyclin D1, and carcinoma staging.

Stages		n	Rb		Cyclin D1		p16
			+	%	+	%	+	%
Pathologic grading	G1	11	9	81.8	8	72.7	6	54.5
	G2	16	10	62.5	11	68.8	8	50
	G3	14	5	35.7	11	78.6	4	28.6
Nevin staging	S1-S2	10	9	90	6	60	8	80
	S3	13	8	61.5	8	61.5	6	46.2
	S4-S5	18	7	38.8	14	77.8	6	33.3

Table 3 Relationship between expressions of Rb, cyclin D1 and p16 in gallbladder carcinoma.

p16	Rb		Cyclin D1		Total
	+	-	+	-
+	8	12	10	10	20
-	16	5	18	3	21
Total	24	17	28	13	41