Polymorphisms in sulfotransferase 1A1 and glutathione S-transferase P1 genes in relation to colorectal cancer risk and patients’ survival

Table 1 Polymorphisms of SULT1A1 and GSTP1 in colorectal cancer patients and healthy controls

Gene	Patients(%)	Controls(%)	Odds ratio(95%CI)	P
SULT1A1
*1/*1	43 (39)	266 (40)	1.0
*1/*2	27 (25)	303 (45)	0.55 (0.32–0.94)
*2/*2	39 (36)	97 (15)	2.49 (1.48–4.19)	0.00021
Allele *1	113 (52)	835 (63)	1.0
Allele *2	105 (48)	497 (37)	1.56 (1.16–2.10)	0.002
GSTP1
A/A	59 (47)	127 (50)	1.0
A/G	51 (41)	101 (40)	1.09 (0.67–1.76)
G/G	15 (12)	27 (10)	1.20 (0.56–2.55)	0.632
A allele	169 (68)	355 (70)	1.0
G allele	81(32)	155 (30)	1.10 (0.78–1.54)	0.57

¹SULT1A1: *2/*2 vs *1/*1+*1/*2,

²GSTP1: G type (G/G+A/G) vs A type (A/A).

Table 2 Multivariate analysis of GSTP1, gender, age, site, Dukes’ stage, growth pattern, and histological type in relation to survival in colorectal cancer

Variable	Number	Cancer deathRate ratio	95%CI	P
GSTP1 genotype
A/A	14	1.0	–	0.03
A/G+G/G	26	5.3	1.26–19.53
Gender				0.09
Male	25	1.0	–
Female	15	0.2	0.05–1.18
Age				0.37
≤70	15	1.0	–
>70	25	1.9	0.51–7.94
Tumor location				1.00
Colon	21	1.0	–
Rectum	19	1.0	0.26–3.98
Dukes’ stage				1.16
A+B	19	1.0	–
C+D	21	2.7	0.69–10.72
Growth pattern				0.08
Expansive	24	1.0	–
Infiltration	16	4.1	0.85–19.45
Histological type				0.02
Non-mucinous	27	1.0	–
Mucinous	13	7.1	1.39–32.07