Polymorphisms in sulfotransferase 1A1 and glutathione S-transferase P1 genes in relation to colorectal cancer risk and patients&rsquo; survival

doi:10.3748/wjg.v11.i43.6875

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 21, 2005; 11(43): 6875-6879
Published online Nov 21, 2005. doi: 10.3748/wjg.v11.i43.6875

Polymorphisms in sulfotransferase 1A1 and glutathione S-transferase P1 genes in relation to colorectal cancer risk and patients’ survival

Xiao-Feng Sun, Ahmad Ahmadi, Gunnar Arbman, Åsa Wallin, Daniel Asklid, Hong Zhang

Xiao-Feng Sun, Åsa Wallin, Department of Oncology, Institute of Biomedicine and Surgery, University of Linköping, Linköping, Sweden

Ahmad Ahmadi, Daniel Asklid, Hong Zhang, Department of Cell Biology, Institute of Biomedicine and Surgery, University of Linköping, Linköping, Sweden

Gunnar Arbman, Department of Surgery, Vrinnevi Hospital, Norrköping, Sweden

Author contributions: All authors contributed equally to the work.

Supported by grants from the Swedish Cancer Foundation and the Health Research Council in the South-East of Sweden

Correspondence to: Xiao-Feng Sun, Professor, MD, PhD, Department of Oncology, Institute of Biomedicine and Surgery, University of Linköping, S-581 85 Linköping, Sweden. xiasu@ibk.liu.se

Telephone: +46-13-222066 Fax: +46-13-222846

Received: March 9, 2005
Revised: April 1, 2005
Accepted: April 2, 2005
Published online: November 21, 2005

Abstract

AIM: To examine whether polymorphisms in SULT1A1 and GSTP1 genes contribute to colorectal cancer development and whether they are associated with clinicopathological variables are not well identified.

METHODS: We examined the genotypes of 125 colorectal cancer patients and 666 healthy controls in a Swedish population by using PCR-restriction fragment length polymorphism (RFLP).

RESULTS: SULT1A1 *2/*2 genotype (OR = 2.49, 95%CI = 1.48-4.19, P = 0.0002) and *2 allele (OR = 1.56, 95%CI = 1.16-2.10, P = 0.002) had an effect on colorectal cancer susceptibility, while GSTP1 genotype was without effect. However, GSTP1 G-type predicted a worse prognosis in the patients independently of gender, age, Dukes’ stage, growth pattern, and differentiation (P = 0.03).

CONCLUSION: Polymorphism in SULT1A1 may predispose to colorectal cancer and GSTP1 may be a biological indicator of prognosis in the patients.

Keywords: GSTP1, SULT1A1, Survival, Colorectal cancer, PCR-RFLP