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©2005 Baishideng Publishing Group Inc.
World J Gastroenterol. Nov 7, 2005; 11(41): 6477-6482
Published online Nov 7, 2005. doi: 10.3748/wjg.v11.i41.6477
Published online Nov 7, 2005. doi: 10.3748/wjg.v11.i41.6477
Table 1 Effect of aFGF on the apoptotic rates in intestinal villi and crypts after ischemia-reperfusion insult (n = 6, mean±SD, %)
Groups | Villus | Crypt | ||
R group | A group | R group | A group | |
C group | 37.3 ± 8.6 | 37.3 ± 8.6 | 14.4 ± 3.8 | 14.4 ± 3.8 |
I group | 40.0 ± 6.9 | 40.0 ± 6.9 | 13.7 ± 4.1 | 13.7 ± 4.1 |
0.25 h after reperfusion | 45.3 ± 5.7 | 35.2 ± 6.7c | 15.0 ± 3.2 | 11.8 ± 2.6 |
0.5 h after reperfusion | 46.3 ± 8.3 | 37.8 ± 7.4 | 16.2 ± 4.7 | 13.0 ± 3.5 |
1 h after reperfusion | 49.5 ± 5.3 | 45.3 ± 7.4 | 19.3 ± 5.6 | 16.2 ± 3.3 |
2 h after reperfusion | 70.2 ± 6.5a | 50.5 ± 5.3ac | 23.5 ± 6.2a | 17.8 ± 4.1c |
6 h after reperfusion | 76.8 ± 4.7a | 49.2 ± 5.0ac | 27.2 ± 4.8a | 19.3 ± 5.0ac |
12 h after reperfusion | 84.0 ± 6.2a | 52.5 ± 4.6ac | 28.0 ± 3.9a | 20.5 ± 5.2ac |
24 h after reperfusion | 41.8 ± 5.4 | 35.2 ± 5.2 | 14.2 ± 4.3 | 9.3 ± 3.6 |
48 h after reperfusion | 33.7 ± 4.8 | 34.3 ± 6.2 | 13.3 ± 2.9 | 11.0 ± 4.3 |
Table 2 Effect of aFGF on protein expression of PCNA in intestinal villi and crypts after ischemia-reperfusion (n = 6, mean±SD, %)
Villus | Crypt | |||
Groups | R group | A group | R group | A group |
C group | 8.5 ± 5.0 | 8.5 ± 5.0 | 31.5 ± 5.2 | 31.5 ± 5.2 |
I group | 8.8 ± 5.3 | 8.8 ± 5.3 | 33.3 ± 4.1 | 33.3 ± 4.1 |
0.25 h after reperfusion | 10.5 ± 5.1 | 10.7 ± 4.9 | 39.7 ± 5.4 | 36.0 ± 5.6 |
0.5 h after reperfusion | 11.5 ± 3.8 | 14.7 ± 4.3 | 41.0 ± 4.7a | 43.8 ± 5.2a |
1 h after reperfusion | 12.3 ± 6.2 | 11.3 ± 5.4 | 44.3 ± 4.6a | 51.5 ± 6.0a |
2 h after reperfusion | 16.7 ± 4.5a | 23.3 ± 5.1ac | 48.2 ± 5.3a | 67.8 ± 5.3ac |
6 h after reperfusion | 18.2 ± 3.5a | 25.0 ± 6.4ac | 47.3 ± 5.5a | 76.0 ± 3.8ac |
12 h after reperfusion | 19.0 ± 5.4a | 25.3 ± 4.5ac | 52.1 ± 5.1a | 79.8 ± 5.2ac |
24 h after reperfusion | 8.7 ± 4.7 | 11.2 ± 2.3 | 43.7 ± 5.4 | 44.8 ± 6.2 |
48 h after reperfusion | 6.7 ± 2.9 | 9.2 ± 4.0 | 38.5 ± 6.1 | 42.7 ± 4.9 |
Table 3 Effect of aFGF on plasma D-lactate levels after intestinal ischemia-reperfusion (n = 6, mean±SD, μg/mL)
Groups | R group | A group |
C group | 0.201 ± 0.008 | 0.201 ± 0.008 |
I group | 0.212 ± 0.011 | 0.212 ± 0.011 |
0.25 h after reperfusion | 0.247 ± 0.011 | 0.225 ± 0.016c |
0.5 h after reperfusion | 0.281 ± 0.036a | 0.222 ± 0.020c |
1 h after reperfusion | 0.285 ± 0.068a | 0.233 ± 0.022 |
2 h after reperfusion | 0.283 ± 0.031a | 0.232 ± 0.018ac |
6 h after reperfusion | 0.293 ± 0.033a | 0.252 ± 0.014ac |
12 h after reperfusion | 0.299 ± 0.025a | 0.250 ± 0.018ac |
24 h after reperfusion | 0.228 ± 0.012 | 0.223 ± 0.015 |
48 h after reperfusion | 0.231 ± 0.004 | 0.224 ± 0.009 |
- Citation: Chen W, Fu XB, Ge SL, Sun TZ, Li WJ, Sheng ZY. Acid fibroblast growth factor reduces rat intestinal mucosal damage caused by ischemia-reperfusion insult. World J Gastroenterol 2005; 11(41): 6477-6482
- URL: https://www.wjgnet.com/1007-9327/full/v11/i41/6477.htm
- DOI: https://dx.doi.org/10.3748/wjg.v11.i41.6477