Expression and correlation of CD44v6, vascular endothelial growth factor, matrix metalloproteinase-2, and matrix metalloproteinase-9 in Krukenberg tumor

Table 1 Expression of CD44v6, VEGF, MMP-2, and MMP-9 in epithelial ovarian carcinoma, Krukenberg tumor, and gastric carcinoma

		CD44v6		VEGF		MMP-2		MMP-9
	n	n	%	n	%	n	%	n	%
Normal ovarian tissue	20	2	10.0	1	5.0	–	–
Epithelial ovarian cancer	45	16	35.6	14	31.1	8	17.8	6	13.3
Serous adenocarcinoma	15	6	40.0	7	46.7	4	26.7	3	20.0
Mucous adenocarcinoma	16	4	25.0	3	18.8	2	12.5	2	12.5
Other types	14	6	42.9	4	28.6	2	14.3	1	7.1
Krukenberg tumor	38	27	71.1	27	71.1	31	81.6	31	81.6
Moderate differentiation	14	9	64.3	10	71.4	12	85.6	10	71.4
Poor differentiation	24	18	75.0	17	70.8	19	79.2	21	87.5
Gastric carcinoma	38	30	78.9	27	73.7	25	65.8	23	60.5
High and moderate differentiation	16	12	75.0	9	56.3	7	31.8	6	37.5
Poor differentiation	22	18	81.8	16	72.7	18	81.8	17	77.3

Table 2 Relation between expressions of CD44v6, VEGF, MMP-2, and MMP-9 in Krukenberg tumor

	CD44v6		MMP-2		MMP-9
	r	P	r	P	r	P
VEGF	0.342	0.023	0.498	0.000	0.498	0.000
CD44v6			0.419	0.005	0.213	0.212
MMP-2					0.488	0.001

Table 3 Relation between expressions of CD44v6, VEGF, MMP-2, and MMP-9 in primary epithelial ovarian carcinoma

	CD44v6		MMP-2		MMP-9
	r	P	r	P	r	P
VEGF	0.605	0.004	0.608	0.003	0.711	0
CD44v6			0.684	0.001	0.804	0
MMP-2					0.457	0.037

Table 4 Relation between expressions of CD44v6, VEGF, MMP-2, and MMP-9 in primary gastric carcinoma

	CD44v6		MMP-2		MMP-9
	r	P	r	P	r	P
VEGF	0.366	0.046	0.25	0.378	0.385	0.035
CD44v6			0.46	0.011	0.200	0.475
MMP-2					0.439	0.015