Protective effect of Astragalus membranaceus on intestinal mucosa reperfusion injury after hemorrhagic shock in rats

Table 1 Status of animals in each group (mean±SD)

Group	n	Weight (g)	Ambienttemperature (°C)	Bloodlettingvolume (mL)
Normal	8	265±18	26.38±1.06	--------
Model	8	281±20	26.67±0.52	5.10±1.80
Low dose	8	269±14	25.88±1.13	5.20±1.60
High dose	8	272±16	26.20±1.10	4.80±1.50

Table 2 Changes of MBP (kPa) and HR (bmp) during shock and reperfusion period (mean±SD)

Groups /n		Pre-shock	30 min of shock	10 min after reperfusion	30 min after reperfusion	60 min after reperfusion	90 min after reperfusion
Normal	MABP	12.66±1.28
( n = 8)	HR	316.50±22.12	--------	------
Model	MABP	12.68±0.82	5.33±0.25 d	12.66±1.35	12.83±1.60	11.65±0.68	11.60±1.82
(n = 8)	HR	322.50±28.12	239.75±35.50 d	256.40±35.63b	292.55±41.96	325.36±36.81	309.25±38.68
Low dose	MABP	13.07±1.27	5.32±0.20 d	13.21±1.17	12.46±1.46	12.21±0.82	12.05±1.58
(n = 8)	HR	320.87±38.83	221.75±49.89 d	250.00±45.63b	282.76±45.63	319.50±42.28	300.62±32.28
High dose	MABP	13.00±1.36	5.30±0.20 d	12.16±1.35	12.90±1.60	12.05±0.82	11.82±1.42
(n = 8)	HR	310.83±25.63	236.16±51.67b	266.00±38.10 b	316.83±30.91	306.66±22.11	298.50±22.11

^bP<0.01 vs pre-shock,

^dP<0.01 vs pre-shock.

Table 3 Effects of Astragalus membranaceus on LD, NO, MDA and SOD GSH-PX during hemorrhagic shock-resuscitation (mean±SD)

Group	n	Chiu‘s score	Lactic acidnmol/gpro	NOnmol/100 mg	ETPg/100 mg	MDA contentnmol/100 mg	SOD activity(U/100 mg)	GSH-PX activity(U/100 mg)
Normal	8	0.90±0.86	2.62±0.45	41.27±8.60	274.62±44.2	28.89±4.90	42.42±4.37	58.04±7.18
Model	8	6.25±2.75b	3.11±0.53a	20.21±4.14b	481.50±109.98b	62.70±15.37b	27.85±10.75b	42.92±10.62a
Low dosage	8	4.05±1.96bc	3.00±0.36a	26.86±5.33ae	414.53±26.15bce	36.80±9.35bd	39.13±7.62ace	55.91±11.27ae
High dosage	8	3.27±1.82ac	2.69±0.19a	42.41±9.89d	353.51±31.90ad	31.31±11.45d	54.38±6.84ad	77.78±13.56bd

^aP<0.05,

^bP<0.01 vs normal group,

^cP<0.05,

^dP<0.01 vs low dose group and high dose group,

^eP<0.05 vs low dose group.