Liver Cancer
Copyright ©2005 Baishideng Publishing Group Inc.
World J Gastroenterol. May 28, 2005; 11(20): 3034-3039
Published online May 28, 2005. doi: 10.3748/wjg.v11.i20.3034
Table 1 Characteristics of microsatellite markers analyzed and patterns of microsatellite alteration in HCC.
LocusLocationAllelic size(bp)Heterozygosity (%)Informative casesLOH n(%)MSI n(%)
D1S2431p36.3142–1700.863516(45.7)3(8.57)
D1S4681p36.3173–1910.753513(37.1)3(8.57)
D1S28931p36.2201–2230.474418(40.9)2(4.55)
D1S26941p36.2241–2550.653816(42.1)1(2.63)
D1S4501p36.2243–2670.813817(44.7)1(2.63)
D1S4341p36.2240–2520.614215(35.7)0
RIZ1p36.23023(76.7)0
D1S5071p36.1183–2030.784524(53.3)2(4.44)
D1S1991p36.194–1160.843914(35.9)1(2.56)
D1S2341p36.1268–2940.53714(37.8)3(8.11)
D4S15384q22149–1610.694117(41.5)0
D4S15344q22146–1580.774122(53.7)0
D4S4064q26234–2580.874222(52.4)1(2.38)
D4S16254q27-31182–2100.743813(34.2)1(2.63)
D4S16524q31.1115–1250.753816 (42.1)0
D4S16154q34-qter138–1500.713919(48.7)0
D4S23614q149–1640.74215(35.7)1(2.38)
D4S15544q35184–2080.863714(37.8)0
D4S4264q35177–1910.784125(61)0
D4S29214q35141–1630.564423(52.3)2(4.55)
D8S2648p23121–1450.834319(44.2)1(2.32)
D8S2778p23148–1800.733818(47.4)1(2.63)
D8S17068p23257–2810.884120(48.9)1(2.43)
D8S17218p23170–2120.714021(52.5)0
D8S5208p23179–1990.774020(50.0)2(5.00)
D8S5498p22166–1720.614420(45.5)2(4.55)
D8S2618p22128–1440.794323(53.5)1(2.33)
D8S2988p22155–1670.684423(52.3)1(2.27)
D8S17338p21253–2570.643817(44.7)1(2.63)
D8S17718p21218–2400.774021(52.5)1(2.50)
D16S40816q134117(41.5)1(2.22)
D16S51216q22.1201–2110.774520(44.4)6(13.3)
D16S51516q22.1222–2440.813612(33.3)2(5.56)
D16S50716q24.1175–1950.784420(45.5)4(9.09)
D16S53416q24.2296–3640.874221(50.0)5(11.9)
D16S309116q24.2115–1290.724222(59.5)2(4.76)
D16S42216q24.2188–2120.794223(54.8)2(4.76)
D16S52016q24.3181–1970.844419(43.2)2(4.55)
D16S41316q24.2208–2460.683616(44.4)2(5.56)
D16S49816q24.3131–1490.844623(50.0)1(2.17)
D17S84917p13.3251–2610.693921(53.9)1(2.56)
D17S92617p13.3243–2590.813621(58.3)1(2.78)
D17S83117p13.3224–2460.813725(67.6)3(8.11)
D17S93817p13.1-p13.3164–1820.764221(50.0)0
D17S78617p13.13915(38.5)1(2.56)
D17S52017p13.1135–1570.774015(37.5)2(5.00)
D17S79917p13-p120.84221(50.0)2(4.76)
D17S92117p12186–2000.73915(38.5)0
D17S26117p11.2169–1850.724115(36.6)1(2.44)
TP5317p11.2157–1710.5474(57.1)0
D2S123hMSH-2197–2273637(19.4)
BAT-261163729(24.3)
D5S346APC96–1224118(19.5)
D13S170Rb220–2403247(21.9)
D17S250151–1693335(15.2)
Table 2 Clinicopathologic correlation of LOH in HCC.
ParameterLocusLOH/informative casesP
HBsAgPositiveNegative
D1S289317/311/130.004
D1S50713/211/160.001
D4S40620/262/160.001
D8S27716/222/160.001
D8S26110/2713/160.005
D8S29811/2912/150.008
D8S17337/2410/140.011
D16S51210/3110/140.014
D16S5155/277/90.001
D17S83119/216/160.001
D17S93819/252/140.001
D17S92613/278/90.032
AFP (mg/L)<20≥20
D1S5073/1721/290.001
D16S4139/127/240.009
Liver cirrhosisPresentAbsent
D16S53420/341/90.011
D16S309124/331/90.001
D16S42222/341/80.008
D17S84921/311/80.005
D17S83124/391/80.011
D17S79920/351/70.038
Tumor size ≤3 cm>3 cm
D8S2982/921/350.043
D8S17710/921/310.001
D16S4984/1219/240.007
D17S9263/1118/250.012
Histological gradeWellModerate and poor
D4S4262/1123/300.002
D4S16152/1214/260.04
D4S16522/1117/280.031
D16S4982/1821/290.001
D17S9264/1317/230.012
Tumor capsuleAbsent or not intactIntact
D8S172120/281/120.001
Intrahepatic metastasisNot observedObserved
D1S4688/105/250.001
D4S29212/2121/230.023
D8S2982/1021/340.02
D8S17712/919/310.039
D17S9261/1120/250.001
D17S7860/1015/290.004