Construction and clinical significance of a predictive system for prognosis of hepatocellular carcinoma

Table 1 Clinical data of patients in resection group.

Item	Group A (n = 15)	Group B (n = 15)
Sex (m/f)	14 /1	14 /1
Age (yr)	54.7±14.3	48.2±8.4
Mean diameter (cm)	3.2±1.0	2.9±1.1
Child-pugh grade	A	A
Serum AFP (mg/L)	180±200	120±200
ALT (U/L)	58.0±54.1	64.9±56.6
AST (U/L)	49.9±46.8	42.0±37.7
HBsAg positive rate	87% (13/15)	100 (15/15)

Table 2 Clinical data of patients in PMCT group.

Item	Group A (n = 25)	Group B (n = 16)
Sex (m/f)	21/4	15/1
Age (yr)	55.8±13.4	57.2±11.2
Mean diameter (cm)	3.5±1.0	3.0±0.8
Child-pugh grade	A	A
Serum AFP (mg/L)	160±200	120±160
ALT (U/L)	52.0±42.5	48.1±40.1
AST (U/L)	51.9±38.9	41.2±36.5
HBsAg positive rate	76% (16/21)	95 (20/21)

Table 3 Expressing intensity of detected molecules in cancer tissue in groups A and B.

Molecule	Group A	Group B
AFP	2.72±2.93	1.55±3.00
c-erbB-2	9.44±5.02	6.82±6.10
c-met	2.04±2.68	1.61±3.22
c-myc	3.95±2.81b	1.34±2.74
HBsAg	0.45±0.96	2.26±5.04
HCV	0.51±1.40	0.96±2.44
Ki-67	1.57±2.20a	0.18±0.38
MMP-2	3.70±4.13a	0.61±1.70
Nm23-H1	2.18±3.05	1.49±2.20
P53	1.31±3.37	0.39±1.16
VEGF	5.44±4.20b	1.04±3.38

^aP<0.05,

^bP<0.01 vs group B.

Table 4 Expressing intensity of 11 detected molecules in para-cancer tissue in groups A and B.

Molecule	Group A	Group B
AFP	0.09±0.35	0.00±0.00
c-erbB-2	0.76±2.50	0.01±0.04
c-met	0.00±0.00	0.00±0.00
c-myc	0.00±0.00	0.26±1.00
HbsAg	9.02±5.83	9.11±6.19
HCV	1.32±2.88	0.08±0.20
Ki-67	0.57±2.22	0.01±0.04
MMP-2	0.80±3.10	0.00±0.00
Nm23-H1	0.33±0.81	0.00±0.00
P53	0.00±0.00	0.00±0.00
VEGF	0.04±0.15	0.00±0.00

Table 5 Variables in the regression equation.

		B	SE	Wald	df	Sig	Exp (B)	95.0% CI for EXP (B)
								Lower	Upper
Step 1	MYCC	–0.357	0.213	2.807	1	0.094	0.700	0.461	1.063
	KI-67C	–2.118	1.251	2.865	1	0.091	0.120	0.010	1.397
	MMP-2C	–0.244	0.306	0.638	1	0.425	0.783	0.430	1.426
	VEGFC	–0.367	0.160	5.269	1	0.022	0.693	0.506	0.948
	Constant	3.680	1.363	7.289	1	0.007	39.64
Step 2	MYCC	–0.412	0.211	3.795	1	0.051	0.663	0.438	1.003
	KI-67C	–2.187	1.271	2.959	1	0.085	0.112	0.009	1.356
	VEGFC	–0.397	0.159	6.222	1	0.013	0.672	0.492	0.918
	Constant	3.663	1.410	6.750	1	0.009	38.991

Variable(s) entered on step 1: MYCC, KI-67C, MMP-2C, VEGFC.

Table 6 Expressing intensity of detected molecules in cancer tissue in groups A and B.

Molecule	Group A	Group B
c-myc	8.31±4.71b	2.52±2.30
Ki-67	1.53±1.79a	0.47±1.19
VEGF	6.23±5.44a	2.88±3.57

^aP<0.05,

^bP<0.01 vs group B.

Table 7 Expressing intensity of detected molecules in para-cancer tissue in groups A and B.

Molecule	Group A	Group B
c-myc	2.20±3.91	0.95±1.84
Ki-67	6.40×103±3.20×102	0.00±0.00
VEGF	0.66±1.84	0.54±2.16