Anticancer activity of resveratrol on implanted human primary gastric carcinoma cells in nude mice

Table 1 Inhibitory effect of resveratrol on implanted tumors in nude mice (mean±SD).

Group	Number of animals		Volume of tumors (mm3)		Inhibition rate%
	Beginning	Ending	Beginning	Ending
Control group
0.2 mL saline	5	5	20.49±0.99	498.73±10.74
DMSO
1500 mg/kg	5	5	20.07±1.24	506.17±8.70
Resveratrol
500 mg/kg	5	5	20.44±1.76	448.04±6.32a	10.58
1000 mg/kg	5	5	21.27±1.73	357.55±6.34a	29.68
1500 mg/kg	5	5	21.32±1.72	312.39±9.93a	39.14

^aP<0.05 vs control group.

Table 2 Apoptotic index (AI) of implanted tumors in nude mice.

	Control	DMSO	500 mg/kg	1000 mg/kg	1500 mg/kg
AI (%)	13.68±0.37	13.80±0.43	48.70±1.07	56.44±1.39	67±0.96
F		0.13	1344.25b	2651.16b	7984.02b
P		>0.05	<0.001	<0.001	<0.001

^bP<0.001 vs control group.

Table 3 Positive rate of bcl-2 proteins of implanted tumors in nude mice.

	Control	DMSO	500 mg/kg	1000 mg/kg	1500 mg/kg
PT(%)	29.48±0.51	27.56±1.40	11.86±0.93	5.70±0.84	3.92±0.85
F		4.98	775.51b	1879.11b	1994.65b
P		>0.05	<0.001	<0.001	<0.001

^bP<0.001 vs control group.

Table 4 Positive rate of bax proteins of implanted tumors in nude mice.

	Control	DMSO	500 mg/kg	1000 mg/kg	1500 mg/kg
PT(%)	19.34±0.35	20.88±0.91	40.02±1.20	45.72±0.88	52.3±1.54
F		7.48	821.11b	2327.70b	1298.41b
P		>0.05	<0.001	<0.001	<0.001

^bP<0.001 vs control group.