Expression of fragile histidine triad in primary hepatocellular carcinoma and its relation with cell proliferation and apoptosis

Table 1 Relationship between FHIT expression and clinicopathological indices of HCC.

	n	FHIT score		P
		-	+
Age (yr)
≤45	18	10	8	0.658
>45	29	18	11
Sex
Male	38	21	18	0.278
Female	9	7	2
Histological grade
I-II	39	21	18	0.119
III	8	7	1
TNM stage
I-II	13	4	9	0.013
III-IV	34	24	10
Tumor size (diameter)
<50 mm	19	12	7	0.68
≥50 mm	28	16	12
Extrahepatic metastasis
Positive	15	13	2	0.01
Negative	32	15	17

Table 2 Relationship between PI, AI and clinicopathological indices (mean±SD).

	N	AI (%)	P value	PI (%)	P value
FHIT expression
Positive	19	9.42±2.85	0.044	28.47±4.22	0.016
Negative	28	8.07±1.63		31.61±4.24
Histological grade
I-II	39	8.87±2.38	0.091	30.46±4.46	0.686
III	8	7.38±1.19		29.75±4.74
TNM stage
I-II	13	7.46±2.30	0.03	28.85±3.85	0.158
III-IV	34	9.06±2.15		30.91±4.60
Tumor size (diameter)
<50 mm	19	8.11±2.03	0.208	29.79±4.85	0.492
≥50 mm	28	8.96±2.41		30.71±4.23
Extrahepatic metastasis
Positive	15	9.00±1.89	0.436	32.53±3.93	0.019
Negative	32	8.44±2.45		29.31±4.38