Protective effect of fufanghuangqiduogan against acute liver injury in mice

Table 1 Effects of FFHQ on serum ALT, AST, TNF-α and IL-1 in immunologic liver injury in mice (n = 10, mean±SD).

Group	Dose (mg/kg b.w.)	ALT (U/L)	AST (U/L)	TNF-α (ng/mL)	IL-1 ng/mL
Normal	---	22.3±6.1	31.5±8.5	1.29±0.41	0.157±0.054
Model	---	204.3±49.6d	197.6±42.3d	3.95±1.24d	0.341±0.101d
FFHQ	60	171.6±33.7a	172.0±35.8a	3.00±0.98a	0.289±0.068a
	120	131.1±24.8b	151.2±39.8b	2.76±0.63b	0.244±0.049b
	240	129.7±26.5b	143.5±30.9b	2.61±0.55b	0.273±0.051b
Bifendate	100	89.6±21.3b	95.4±28.3b	2.89±0.92a	0.279±0.046a

^aP<0.05,

^bP<0.01 vs model group;

^dP<0.01 vs normal group.

Table 2 Effects of FFHQ on serum ALT and AST in chemical ALI in mice (n = 10, mean±SD).

Group	Dose (mg/kg b.w.)	ALT (U/L)	AST (U/L)
Normal	---	26.4±8.2	34.1±9.3
Model	---	222.4±35.9d	231.8±40.0d
FFHQ	60	181.6±30.7a	182.0±35.8a
	120	153.1±34.8b	161.2±39.8b
	240	144.7±46.5b	153.5±30.9b
Bifendate	100	103.5±29.8b	139.3±31.6b

^dP<0.01 vs normal group;

^aP<0.05,

^bP<0.01 vs model group.

Table 3 Effects of FFHQ on MDA, SOD and GSH-px of immunological ALI mice’s liver homogenate (n = 10, mean±SD).

Group	Dose (mg/kg b.w.)	MDA (nmol/g tissue)	SOD (U/g tissue)	GSH-px (U/mg protein)
Normal	---	6.541.82	396.660.6	141.427.5
Model	---	15.183.57d	181.340.7 d	97.924.7d
FFHQ	60	12.573.15a	212.339.8a	116.529.1a
	120	10.742.34b	252.142.0b	129.530.5b
	240	10.082.28b	269.052.7b	133.134.1b
Bifendate	100	12.033.21a	193.840.5	107.630.5

^aP<0.05,

^bP<0.01 vs model group;

^dP<0.01 vs normal group.

Table 4 Effects of FFHQ on MDA, SOD and GSH-px of chemical ALI mice’s liver homogenate (n = 10, mean±SD).

Group	Dose (mg/kg b.w.)	MDA (nmol/g tissue)	SOD (U/g tissue)	GSH-px (U/mg protein)
Normal	---	6.762.3	440.551.8	136.424.5
Model	---	18.684.72d	204.334.1d	91.921.2d
FFHQ	60	13.212.88b	310.135.5 b	105.523.6a
	120	12.363.19b	321.339.2b	121.124.6b
	240	12.083.28b	337.035.1b	124.327.9b
Bifendate	100	12.292.67b	221.638.5	98.322.5

^aP<0.05,

^bP<0.01 vs model group;

^dP<0.01 vs normal group.