Syndecan-1 and E-cadherin expression in differentiated type of early gastric cancer

Table 1 Criteria for cellular phenotype.

	HGM expression	Con A expression	MUC2 expression	CD10 expression
G-type	(+)	(+)	(–)	(–)
O-type	(+)	(+)	(+)	(+)
CI-type	(–)	(–)	(+)	(+)
N-type	(–)	(–)	(–)	(–)

G-type, gastric type; O-type, ordinary type; CI-type, complete-intestinal type; N-type, null type.

Table 2 Correlation of pathological factors and expression of syndecan-1 and E-cadherin in each mucin phenotype.

	G-type (n = 34)	O-type (n = 54)	CI-type (n = 20)	N-type (n = 12)	P
Tumor size (cm, mean±SD)	3.5±0.9	2.9±0.7	3.1±0.6	2.7±0.4	NS
Histology Solely
differentiated type	16	45	18	3	<0.05ac
Complex type	18	9	2	9	<0.05ac
Lymphatic and/or
venous invasion1	17	14	5	5	<0.05eg
Lymph node metastasis	7	8	1	4	NS
Syndecan-1 expression	10	43	18	8	<0.05ac
E-cadherin expression	22	32	15	8	NS
IM	21	41	15	8	NS
IM
with G-type2	5	2	1	0	<0.05a

^aP<0.05 vs O-type;

^cP<0.05 vs CI-type;

^eP<0.05 vs O-type;

^gP<0.05 vs CI-type G-type, gastric type; O-type, ordinary type; CI-type, complete-intestinal type; N-type, null type; NS, not significant.

¹Evaluated in 41 surgically resected specimens with submucosal invasion.

²Evaluated in 85 cases with positive for IM.

Table 3 Correlation of pathological factors and expression of syndecan-1.

	Syndecan-1 expression		P
	Positive (n = 80)	Negative (n = 40)
Histology
Solely differentiated type	66	16	<0.05
Complex type	14	24	<0.05
Lymphatic and/or venous invasion1	28	13	NS
Lymph node metastasis	12	8	NS
IM with G-type2	2	6	<0.05

G-type, gastric type; NS, not significant.

¹Evaluated in 41 surgically resected specimens with submucosal invasion.

²Evaluated in 85 cases with positive for IM.

Table 4 Correlation of pathological factors and E-cadherin.

	E-cadherin expression		P
	Positive (n = 77)	Abnormal (n = 43)
Histology
Solely differentiated type	57	29	NS
Complex type	20	14	NS
Lymphatic and/or venous invasion1	23	18	NS
Lymph node metastasis	7	13	<0.05
IM with G-type2	4	4	NS

G-type, gastric type; NS, not significant.

¹Evaluated in 41 surgically resected specimens with submucosal invasion.

²Evaluated in 85 cases with positive for IM.