Relationship between proliferative activity of cancer cells and clinicopathological factors in patients with esophageal squamous cell carcinoma

Table 1 Relationship between Ki-67, cyclinA and clinicopathologic characteristics of esophageal SCC (mean±SD).

Factor	n	SI
		Ki-67	P	Cyclin A	P
Sex
M	54	23.5±5.9		13.9±6.3
F	16	22.3±6.8	>0.05	12.0±6.1	>0.05
Age (yr)
＜60	29	23.1±6.2		13.8±6.9
≥60	41	22.1±6.9	>0.05	12.5±6.3	>0.05
Histological	grade
Normal	20	3.9±2.1		2.8±1.2
SCC	70	22.6±6.1	<0.01	13.1±6.2	<0.01
Well	26	21.0±6.5		11.5±6.5
Moderate	24	20.3±5.9	<0.05	13.0±6.8
Poor	20	27.4±5.1	<0.05	15.6±5.4	<0.05
Lymphatic	invasion
(-)	39	22.0±6.9		12.6±6.7
(+)	31	24.2±5.2	>0.05	13.1±5.8	>0.05
Location
Cervical	1	24.1		13.3
Upper	8	23.4±6.2		12.7±4.9
Middle	46	22.0±7.1		10.9±6.4
Lower	15	22.3±4.9	>0.05	12.1±5.0	>0.05
Stage
0	1	18.2		7.3
I	15	22.9±6.5		14.0±6.8
II	43	20.6±6.7		12.5±5.8
III	7	23.5±5.9		12.8±5.5
IV	4	24.8±6.2	>0.05	13.1±6.0	>0.05

Cervical: cervical esophagus; upper: upper intra-thoracic esophagus; middle: middle intra-thoracic esophagus; lower: lower intra-thoracic esophagus.