Expressed genes in regenerating rat liver after partial hepatectomy

Table 1 Genes altered at least by more than two fold intensity at one time point after PH.

No.	Gene description	Fold difference
Stress response
1	Alpha-1 major acute phase protein	6.2
2	Acute-phase protein alpha-1-inhibitor 3	0.2
3	Clusterin (Clu)	0.3
4	C-reactive protein, petaxin related	2.2
Glycometabolism
5	Isocitrate dehydrogenase 1 (Idh1)	0.3
6	Glycerol 3-phosphate dehydrogenase (Gpd3)	0.4
7	Aldolase B	0.3
8	Enolase 1	4
9	Small subunit of RuBPCase	3.3, 0.1
Fatty and stearoyl metabolism
10	Acyl-CoA desaturase	0.4
11	3-alpha-hydroxysteroid dehydrogenase	0.2
12	Bile acid CoA ligase	2.3
13	Methylmalonate semialdehyde dehydrogenase	0.3
14	Prostaglandin D2 synthase 2 (Ptgds2)	3
15	Cytochrome P450 cholesterol 7-alpha-hydroxylase (P450 VII)	2.3, 0.5
16	Malonyl-CoA decarboxylase	0.3
17	NAD(P)-dependent steroid dehydrogenase	0.4
Oxidation and reduction response
18	Acyl-coA oxidase (RATACOA1)	2.7, 0.4
19	Cytochrome b5 (Cyb5)	0.2
20	Flavin-containing monooxygenase 1 (Fmo1)	0.1
21	Paraoxonase 1 (Pon1)	0.2
22	Selenium-dependent glutathione peroxidase	0.4
23	Peroxisomal sarcosine oxidase (PSO)	0.3
24	P450 arachidonic acid epoxygenase (cyp 2C23)	0.2
25	Cytochrome P450	0.2
26	Cytochrome P450 15-beta (Cyp2c12)	0.2
27	Cytochrome P450 2E1	0.1
28	Cytochrome P450, 2c39 (Cyp2c39)	0.1
29	Cytochrome P450, 7a1 (Cyp7a1)	2
30	Cytochrome P450 (PNCN inducible, Cyp3A1)	0.2
31	Cytochrome b	0.5
Regulation proteins
32	G-protein, beta polypeptide 2 (Gnb2l1)	2.4
33	Interferon-induced protein with tetratricopeptide repeats 3	0.2
34	Protein RAKb	0.2
Glycoproteins
35	Selenoprotein P (Sepp1)	0.3
36	Myelin-associated glycoprotein (L-MAG)	7
37	Alpha-1-B glycoprotein (A1bg)	0.1
38	Histidine-rich glycoprotein (Hrg)	0.1
39	Mannosylalpha-1, 6-glycoprotein beta-1, 2-N-acetylglucosaminyltransferase (Mgat2)	2
40	UDP-glucuronosyltransferase 2B3 (Udpgt)	0.3
41	Fibrinogen gamma polypeptide (Fgg)	5.1
42	TRAM1	3.3, 0.4
Lipid-proteins
43	Apolipoprotein C-II	0.3
44	Apolipoprotein M (Apom)	0.4
45	Fatty acid binding protein 1 (Fabp1)	0.3
46	Retinol-binding protein(PRBP)	0.4
47	Solute carrier family 20 (phosphate transporter) member 1 (Slc20a1)	0.4
48	Transthyretin-related protein (TTN)	0.3
Nucleolar proteins
49	P53	2
50	Damage-specific DNA binding protein 1 (Ddb1)	0.3
51	Nucleolar protein family A, member 2	3.9
52	Nuclear protein 1 (Nupr1)	5.1
53	AP1 gamma subunit binding protein 1	2.3
Receptors
54	Interleukin 1 receptor, type I (Il1r1)	7.9
55	Golgi SNAP receptor complex member 1 (Gosr1)	0.4
56	Nuclear receptor subfamily 0, member 2 (Nr0b2)	0.2
57	Lysosomal-associated protein transmembrane 4A	0.5
58	ATP-binding cassette, sub-family B	0.4
59	ATP-binding cassette, sub-family C	0.2
Factors
60	Eukaryotic translation initiation factor 4A1	3.8
61	Eukaryotic release factor 3	2
62	Insulin-like growth factor I	0.5
63	Early growth response factor 1 (Egr1)	3.6
64	Neuropeptide Y (Npy)	18.2
65	NF-E2-related factor 2 (Nfe2l2)	0.4
66	Pre-B-cell colony-enhancing factor (Pbef)	3.5
67	Amphoterin	0.3
68	Angiogenin	0.2
69	Angiopoietin-like 3	0.2
70	Ring1 and YY1 binding protein	0.5
71	Chromatin remodeling factor	2
	Hemoglobins
72	Hemoglobin beta chain (Hbb)	0.3
Immunological proteins
73	Immunoglobulin C kappa	0.2
74	Achaete-scute complex homolog-like 1 (Ascl1)	0.4
75	Complement component 1	0.3
76	Complement component 5	8.8
77	JE/MCP-1	4
78	Class III Fc-gamma receptor	3.5
Chaperonins
79	70 ku heat shock protein (Hspa5)	2.8, 0.5
80	DnaJ (Hsp40)	2.5
Cytoskelets
81	Actin gamma	4.7
82	Karyopherin (importin) alpha 2	0.4
83	Clathrin, heavy polypeptide (Cltc)	3.3
Ribosomal proteins
84	Ribosomal protein L28 (Rpl28)	2.2
85	Ribosomal protein L41 (Rpl41)	2.1
86	Ribosomal protein S19	2.5
Marker proteins
87	Probable surface antigen protein	2.1, 0.4
88	Surfeit 1 (Surf1)	2.5
89	Alpha globin	0.3
90	Pregnancy-zone protein (Pzp)	2.4
91	Adipose differentiation-related protein	7.3
92	Subchromosomal-transferable fragment 4	2.3, 0.3
93	Cocoa protein	4.9
94	Amyloid P-component (Sap)	0.4
95	Amyloid alpha-5 protein	0.2
Amino acid enzymes
96	Arginase 1 (Arg1)	0.4
97	2-hydroxyphytanoyl-CoA lyase (Hpcl2)	90.5
98	Cytosolic aspartate aminotransferase	5.3
Nuclearase
99	Mitochondrial adenine nuleotidase	2
100	Rnase A family 4	0.2
101	Rnase H	0.4
	Proteolytic enzymes
102	Caspase 1 (Casp1)	2.6
103	Cathepsin C (Ctsc)	0.4
104	Cathepsin D (Ctsd)	0.3
105	Neutrophil collagenase (Mmp8)	0.2
106	Coagulation factor 2 (F2)	0.2
Proteinase inhibitors
107	Alpha-1 microglobulin/bikunin (Ambp)	2.1, 0.2
108	Alpha-2-macroglobulin (A2m)	21.3
109	Alpha-trypsin inhibitor, heavy chain 4	0.2
110	Leuserpin-2 (Serpind1)	0.2
111	Serine protease inhibitor 1	5
Phopshorylases
112	Thymidylate kinase (dTMP kinase)	3
113	Mss4 protein	2.1
114	CDK110	0.5
Phosphatases
115	Carbamyl phosphate synthetase I	2.9
116	Phosphodiesterase 1(Enpp1)	6.6
117	Phosphatidylserine-specific phospholipase A1	2.8
118	Protein phosphatase 1 (GL-subunit)	0.2
119	UTP-glucose-1-phosphatase	0.4
Synthase
120	H+-ATP synthase alpha subunit (Atp5a1)	2.4, 0.4
121	Bifunctional aminoacyl-tRNA synthetase	0.4
122	ATP synthase subunit 8	2.2
123	Glutamyl-prolyl-tRNA synthetase (Eprs)	4.5
124	Fatty acid elongase 1 (rELO1)	0.2
125	RNA cyclase	0.2
Transferases
126	Carnitine O-octanoyltransferase (Crot)	0.3
127	Glutathione S-transferase, alpha 1 (Gsta1)	0.1
128	Glutathione S-transferase, type 3 (Gstm3)	2.2, 0.3
129	Microsomal glutathione S-transferase 1 (Mgst1)	0.4
130	Sulfotransferase K2	0.3
131	Sialyltransferase 1 (Siat1)	2.6
132	UDP-glucuronosyltransferase member	50.3
(Ugt2b5)	0.5
133	Protein disulfide isomerase-related protein