Copyright
©The Author(s) 2004.
World J Gastroenterol. Apr 1, 2004; 10(7): 940-944
Published online Apr 1, 2004. doi: 10.3748/wjg.v10.i7.940
Published online Apr 1, 2004. doi: 10.3748/wjg.v10.i7.940
Table 1 Risk factors for esophageal cancer
Risk factors | Case | Control | OR | OR95%CI | χ2 | P | |
Tobacco smoking | Yes | 70 | 38 | 2.04 | 1.15-3.60 | 6.88 | 0.009 |
No | 59 | 63 | |||||
Alcohol drinking | Yes | 50 | 16 | 3.45 | 1.74-6.91 | 15.08 | 0.000 |
No | 77 | 85 | |||||
FHEC | Yes | 27 | 8 | 3.14 | 1.28-7.94 | 7.67 | 0.006 |
No | 100 | 93 | |||||
GSTM1 | Deletion | 74 | 44 | 1.81 | 1.03-3.18 | 4.85 | 0.028 |
Existed | 53 | 57 | |||||
CYP1A1 | Ile/Ile | 21 | 31 | 1.00 | |||
Ile/Val | 56 | 48 | 1.72 | 0.83-3.58 | 2.50 | 0.114 | |
Val/Val | 50 | 22 | 3.35 | 1.49-7.61 | 10.33 | 0.001 |
Table 2 Synergic interactions of tobacco smoking and GSTM1 deletion genotype
Tobacco smoking | GSTM1 deletion | Case | Control | OR | OR95%CI | χ2 | P |
No | No | 24 | 37 | 1.00 | |||
No | Yes | 33 | 26 | 2.96 | 0.89-4.33 | 3.28 | 0.07 |
Yes | No | 29 | 20 | 2.24 | 0.97-5.19 | 4.24 | 0.04 |
Yes | Yes | 41 | 18 | 3.51 | 1.55-8.05 | 10.89 | 0.001 |
Table 3 Synergic interactions of alcohol drinking and GSTM1 deletion genotype
Alcohol drinking | GSTM1 deletion | Case | Control | OR | OR95%CI | χ2 | P |
No | No | 35 | 48 | ||||
No | Yes | 42 | 37 | 1.56 | 0.80-3.04 | 1.95 | 0.16 |
Yes | No | 18 | 9 | 2.74 | 1.01-7.55 | 4.85 | 0.03 |
Yes | Yes | 32 | 7 | 6.27 | 2.30-17.72 | 16.91 | 0.00 |
Table 4 Synergic interaction of GSTM1 deletion genotype and family history of esophageal cancer
ECFH | GSTM1deletion | Case | Control | OR | OR95%CI | χ2 | P |
No | No | 44 | 53 | 1.00 | |||
No | Yes | 56 | 40 | 1.69 | 0.92-3.11 | 3.24 | 0.07 |
Yes | No | 9 | 4 | 2.71 | 0.69-12.76 | 2.59 | 0.11 |
Yes | Yes | 18 | 4 | 5.42 | 1.60-23.34 | 9.47 | 0.00 |
Table 5 Interaction of tobacco smoking and CYP1A1 Val/Val genotype
Smoking | CYP1A1 (Val/Val) | Case | Control | OR | OR95%CI | χ2 | P |
No | No | 33 | 47 | 1.00 | |||
No | Yes | 24 | 16 | 2.14 | 0.92-4.99 | 3.73 | 0.05 |
Yes | No | 44 | 32 | 1.96 | 0.99-3.90 | 4.29 | 0.04 |
Yes | Yes | 26 | 6 | 6.17 | 2.14-20.10 | 14.54 | 0.00 |
Table 6 Interaction of alcohol drinking and CYP1A1Val/Val genotype
Alcohol drinking | CYP1A1 Val/Val | Case | Control | OR | OR95%CI | χ2 | P |
No | No | 50 | 67 | 1.00 | |||
No | Yes | 27 | 18 | 2.01 | 0.94-3.43 | 3.86 | 0.05 |
Yes | No | 27 | 12 | 3.02 | 1.31-7.03 | 8.16 | 0.00 |
Yes | Yes | 23 | 4 | 7.71 | 2.39-32.16 | 15.71 | 0.00 |
Table 7 Interaction of CYP1A1 Val/Val genotype and a family history of esophageal cancer
ECFH | CYP1A1 Val/Val | Case | Control | OR | OR95%CI | χ2 | P |
No | No | 65 | 74 | 1.00 | |||
No | Yes | 35 | 19 | 2.10 | 1.04-4.24 | 5.05 | 0.03 |
Yes | No | 12 | 5 | 2.73 | 0.84-10.38 | 3.42 | 0.06 |
Yes | Yes | 15 | 3 | 5.69 | 1.50-31.72 | 8.47 | 0.00 |
- Citation: Wang AH, Sun CS, Li LS, Huang JY, Chen QS, Xu DZ. Genetic susceptibility and environmental factors of esophageal cancer in Xi’an. World J Gastroenterol 2004; 10(7): 940-944
- URL: https://www.wjgnet.com/1007-9327/full/v10/i7/940.htm
- DOI: https://dx.doi.org/10.3748/wjg.v10.i7.940