Esophageal Cancer
Copyright ©The Author(s) 2004. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 1, 2004; 10(7): 940-944
Published online Apr 1, 2004. doi: 10.3748/wjg.v10.i7.940
Genetic susceptibility and environmental factors of esophageal cancer in Xi’an
An-Hui Wang, Chang-Sheng Sun, Liang-Shou Li, Jiu-Yi Huang, Qing-Shu Chen, De-Zhong Xu
An-Hui Wang, Chang-Sheng Sun, Liang-Shou Li, Jiu-Yi Huang, De-Zhong Xu, Department of Epidemiology, Faculty of Preventive Medicine, Fourth Military Medical University, Xi’an 710033, Shanxi Province, China
Qing-Shu Chen, Department of Thoracic Surgery, Tangdu Hospital, Fourth Military Medical University, Xi’an 710038, Shanxi Province, China
Author contributions: All authors contributed equally to the work.
Supported by the National Natural Science Foundation of China, No.39670651
Correspondence to: Dr. An-Hui Wang, Department of Epidemiology, Faculty of Preventive Medicine, Fourth Military Medical University, Xi’an 710033, Shanxi Province, China. wanganhui@hotmail.com
Telephone: +86-29-3374871
Received: July 18, 2002
Revised: October 23, 2002
Accepted: April 1, 2003
Published online: April 1, 2004
Abstract

AIM: To analyse the role of genetic susceptibility and environmental factors in the process of esophageal cancer (EC) formation in Xi’an, China.

METHODS: A hospital based case-control study, combined with molecular epidemiological method, was carried out. A total of 127 EC cases and 101 controls were interviewed with questionnaires containing demographic items, habit of tobacco smoking, alcohol drinking, and family history of EC. Polymorphism of CYP1A1 and GSTM1 of 127 EC cases and 101 controls were detected by PCR method. The interactions between genetic susceptibility and environmental factors were also discussed.

RESULTS: Tobacco smoking, alcohol drinking and a family history of EC were risk factors for EC with an OR of 2.04 (95%CI 1.15-3.60), 3.45(95%CI 1.74-6.91), 3.14 (95%CI 1.28-7.94), respectively. Individuals carrying CYP1A1 Val/Val genotype compared to those with CYP1A1 Ile/Ile genotype had an increased risk for EC (OR 3.35, 95%CI 1.49-7.61). GSTM1 deletion genotype was a risk factor for EC (OR1.81, 95%CI 1.03-3.18). Gene-environment interaction analysis showed that CYP1A1 Val/Val genotype, GSTM1 deletion genotype had synergetic interactions with tobacco smoking, alcohol drinking and family history of EC.

CONCLUSION: Tobacco smoking, alcohol drinking and a family history of EC are risk factors for EC. CYP1A1 Val/Val and GSTM1 deletion genotypes are genetic susceptibility biomarkers for EC. There are synergic interactions between genetic susceptibility and environmental factors.

Keywords: $[Keywords]