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©The Author(s) 2004.
World J Gastroenterol. Mar 15, 2004; 10(6): 776-782
Published online Mar 15, 2004. doi: 10.3748/wjg.v10.i6.776
Published online Mar 15, 2004. doi: 10.3748/wjg.v10.i6.776
Table 1 Relationship between clinicopathological features and heparanase mRNA expression and CD44v6, nm23 and MMP-7 protein expression in primary gastric carcinomas
Number of patients | ||||||||||||
Heparanase | CD44v6 | nm23 | MMP-7 | |||||||||
(+) | (-) | P value | (+) | (-) | P value | (+) | (-) | P value | (+) | (-) | P value | |
Gender | 0.307 | 0.481 | 0.280 | 0.415 | ||||||||
Female | 13 | 4 | 12 | 5 | 8 | 9 | 9 | 8 | ||||
Male | 16 | 10 | 21 | 5 | 8 | 18 | 17 | 9 | ||||
Tumor location | 0.216 | 0.346 | 0.903 | 0.804 | ||||||||
Upper third | 9 | 1 | 9 | 1 | 4 | 6 | 6 | 4 | ||||
Middle third | 4 | 3 | 6 | 1 | 3 | 4 | 5 | 2 | ||||
Lower third | 16 | 10 | 18 | 8 | 9 | 17 | 15 | 11 | ||||
Gross type | 0.242 | 0.325 | 0.025 | 0.121 | ||||||||
Borrmann I | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | ||||
Borrmann II | 4 | 5 | 5 | 4 | 7 | 2 | 5 | 4 | ||||
Borrmann III | 21 | 9 | 25 | 5 | 9 | 21 | 20 | 10 | ||||
Borrmann IV | 3 | 0 | 2 | 1 | 0 | 3 | 0 | 3 | ||||
Histologic type | 0.671 | 0.297 | 0.444 | 0.325 | ||||||||
Adenocarcinoma | 19 | 11 | 23 | 7 | 13 | 17 | 20 | 10 | ||||
Mucinous carcinoma | 4 | 1 | 5 | 0 | 1 | 4 | 3 | 2 | ||||
Signet-ring cell | 6 | 2 | 5 | 3 | 2 | 6 | 3 | 5 | ||||
carcinoma | ||||||||||||
Peritoneal metastasis | 0.539 | 1.000 | 0.045 | 0.266 | ||||||||
Absent | 26 | 14 | 30 | 10 | 13 | 27 | 23 | 17 | ||||
Present | 3 | 0 | 3 | 0 | 3 | 0 | 3 | 0 | ||||
Liver metastasis | 1.000 | 1.000 | 0.133 | 0.511 | ||||||||
Absent | 27 | 14 | 31 | 10 | 14 | 27 | 24 | 17 | ||||
Present | 2 | 0 | 2 | 0 | 2 | 0 | 2 | 0 | ||||
Histologic differentiation | 1.000 | 0.704 | 0.888 | 0.101 | ||||||||
Well/moderate | 9 | 5 | 10 | 4 | 5 | 9 | 6 | 8 | ||||
Poorly | 20 | 9 | 23 | 6 | 11 | 18 | 20 | 9 | ||||
Serosal invasion | 0.009 | 0.010 | 0.101 | 0.042 | ||||||||
Absent | 2 | 6 | 3 | 5 | 5 | 3 | 2 | 6 | ||||
Present | 27 | 8 | 30 | 5 | 11 | 24 | 24 | 11 | ||||
Lymph node metastasis | 0.018 | 0.024 | 0.008 | 0.084 | ||||||||
Absent | 7 | 9 | 9 | 7 | 10 | 6 | 7 | 9 | ||||
Present | 22 | 5 | 24 | 3 | 6 | 21 | 19 | 8 | ||||
Distant metastasis | 0.039 | 0.656 | 0.125 | 1.000 | ||||||||
Absent | 21 | 14 | 26 | 9 | 11 | 24 | 21 | 14 | ||||
Present | 8 | 0 | 7 | 1 | 5 | 3 | 5 | 3 | ||||
TNM stage | 0.001 | 0.001 | 0.228 | 0.021 | ||||||||
I-II | 4 | 10 | 6 | 8 | 7 | 7 | 5 | 9 | ||||
III-IV | 25 | 4 | 27 | 2 | 9 | 20 | 21 | 8 |
Table 2 Correlation between the expression of heparanase mRNA and the expression of CD44v6, nm23 and MMP-7 protein
Items | Numberof cases | Heparanase(+) | Correlationcoefficient | P value |
CD44v6 | -0.440 | 0.004 | ||
(-) | 10 | 3 | ||
(+) | 33 | 26 | ||
Nm23 | -0.021 | 0.889 | ||
(-) | 27 | 18 | ||
(+) | 16 | 11 | ||
MMP-7 | -0.352 | 0.023 | ||
(-) | 17 | 8 | ||
(+) | 26 21 |
- Citation: Chen JQ, Zhan WH, He YL, Peng JS, Wang JP, Cai SR, Ma JP. Expression of heparanase gene, CD44v6, MMP-7 and nm23 protein and their relationship with the invasion and metastasis of gastric carcinomas. World J Gastroenterol 2004; 10(6): 776-782
- URL: https://www.wjgnet.com/1007-9327/full/v10/i6/776.htm
- DOI: https://dx.doi.org/10.3748/wjg.v10.i6.776