Effects of low molecular weight heparin on platelet surface P-selectin expression and serum interleukin-8 production in rats with trinitrobenzene sulphonic acid-induced colitis

Table 1 Effect of low molecular weight heparin (dalteparin) in Fedorak grades on mucosa of TNBS-induced colitis in rats

	n	24 h	Day 7	Day 14
Control group	5	1.33 ± 0.54	4.33 ± 0.81b	3.67 ± 2.13
150 U/kg LMWH group	4	1.00 ± 0.00	3.33 ± 2.08	1.67 ± 1.15
300 U/kg LMWH group	5	0.57 ± 0.33	2.00 ± 1.33	0.66 ± 0.32d

^bP < 0.01 vs control group at 24 h;

^dP < 0.01 vs control group on day 14.

Table 2 Effect of low molecular weight heparin (dalteparin) on scores of mucosal TNF-α expression in rats with TNBS- in-duced colitis

	n	24 h	d 7	d 14
Control group	5	217 ± 44a	48 ± 11	50 ± 18
150 U/kg LMWH group	4	264 ± 42a	46 ± 21	48 ± 16
300 U/kg LMWH group	5	198 ± 38ab	26 ± 18	16 ± 8

^aP < 0.001 vs control group on day 7 and 14;

^bP < 0.05 vs 150 U/kg group at 24 h.

Table 3 Effects of low molecular weight heparin (dalteparin) on platelet surface P-selectin expression (moleculars/per platelet) in rats with TNBS-induced colitis

	n	24 h	d 7	d 14
Control group	5	177.50 ± 88.60	657.23 ± 300.90a	767.50 ± 359.11b
150 U/kg	4	193.67 ± 59.98	521.95 ± 200.10	534.61 ± 16.13
LMWH group
300 U/kg	5	211.72 ± 72.23	598.23 ± 233.70	653.90 ± 286.70
LMWH group

^aP < 0.05 vs control group at 24 h;

^bP < 0.01 vs control group at 24 h.

Table 4 Effects of low molecular weight heparin (dalteparin) on production of serum IL-8 (pg/ml) in rats with TNBS-in-duced colitis

	n	24 h	d 7	d 14
Control group	5	7.50 ± 3.50	4.51 ± 2.59	4.53 ± 3.37
150 U/kg LMWH group	4	8.38 ± 4.01	5.04 ± 2.01	4.44 ± 2.88
300 U/kg LMWH group	5	8.11 ± 3.87	3.09 ± 1.28	2.06 ± 1.03a

^aP < 0.05 vs 300 U/kg LMWH group at 24 h.