Effects of tumor necrosis factor, endothelin and nitric oxide on hyperdynamic circulation of rats with acute and chronic portal hypertension

doi:10.3748/wjg.v10.i5.689

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Mar 1, 2004 (publication date) through Mar 10, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Mar 1, 2004; 10(5): 689-693
Published online Mar 1, 2004. doi: 10.3748/wjg.v10.i5.689

Table 1 Serum levels of TNFα, ET-1 and NO and hepatic NOS activities in PVL and cPHT rats

Groups	TNFα	ET-1	NO	NOS
Groups	(pg/min)	(pg/min)	(µmol/L)	(u/mg·prot)
Control	48.67 ± 32.79	8.72 ± 0.79	113 ± 15	0.9 ± 0.03
aPHT
PVL0.5 h	50 ± 15	13.4 ± 2.6	128.64 ± 18.29	0.86 ± 0.14
PVL24 h	328 ± 100^a^c	12.8 ± 5.7	169.40 ± 21.07^a^c	1.45 ± 0.17^a^c
PVL48 h	428 ± 69^a	13.5 ± 2.6	223.71 ± 35.44^a	1.7 ± 0.12^a
PVL72 h	416 ± 48^a	13.1 ± 3.2	215.49 ± 12.75^a	1.67 ± 0.16^a
PVL120 h	425 ± 49^a	13.4 ± 3.5	225.36 ± 18.66^a	1.7 ± 0.12^a
cPHT	477.67 ± 83.81^a^e	14.33 ± 4.42	278.41 ± 20.11^a^e	1.81 ± 0.06^a

^aP < 0.05 vs control,

^cP < 0.05 PVL 24 h group compared with PVL 48 h, 72 h, 120 h and cPHT groups respectively,

^eP < 0.05 cPHT group compared with PVL 48 h, 72 h, 120 h groups respectively.

Table 2 Effects of anti-rat TNFa and L-NMMA on levels of TNFa, ET-1 and hepatic NO and NOS activity in PVL and cPHT rats

Groups	TNFα (pg/mL)	ET-1 (pg/mL)	NO (µmol/L)	NOS (u/mg·prot)
Control	48.67 ± 32.29	8.72 ± 0.79	113 ± 15	0.9 ± 0.03
cPHT	477.67 ± 83.8^a^c	14.33 ± 4.42	278.41 ± 20.11^a^c	1.81 ± 0.06^a^c
cPHT+anti-rat TNFα	15.17 ± 18.79^a	14.33 ± 4.42	190.61 ± 10.9^a	1.39 ± 0.04^a
cPHT+L-NMMA	-	-	119.18 ± 11.51^e	4.92 ± 0.03^e
PVL72 h	416 ± 48^a^g	13.1 ± 3.2	215.49 ± 12.75^a^g	1.67 ± 0.16^a^g
PVL72 h+anti-rat TNFα	14 ± 14^a	13.5 ± 2.6	178.59 ± 14.61^a	1.34 ± 0.09^a
PVL72 h+L-NMMA	-	-	104.61 ± 18ⁱ	0.95 ± 0.08ⁱ

^aP < 0.05 vs control,

^cP < 0.05 cPHT group compared with cPHT+anti-rat TNFα and cPHT+L-NMMA groups respectively,

^eP < 0.05 cPHT+anti-rat TNFα compared with cPHT+L-NMMA groups,

^gP < 0.05 PVL72 h group compared with PVL72 h+anti-rat TNFα and PVL72 h+L-NMMA groups respectively,

ⁱP < 0.05 PVL72 h+anti-rat TNFα compared with PVL72 h+L-NMMA.

Table 3 Effects of anti-rat TNFα and L- NMMA on homodynamic variables

Groups	SV	CO	PP	SMAflow	IAflow	VR_SMA	VR_IA
Groups	(mL/s)	(L/min)	(kPa)	(mL/min)	(mL/min)	(kPa/.L·min)	(kPa/.L·min)
Control	0.162 ± 0.04	0.05 ± 0.017	0.91 ± 0.16	8.42 ± 1.16	10 ± 0.89	15.57 ± 2.74	13.58 ± 2.19
cPHT	0.59 ± 0.06^a^c	0.159 ± 0.031^a^c	2.26 ± 0.34^a^c	27 ± 3.19^a^c	27.33 ± 1.21^a^c	4.07 ± 0.43^a^c	4.44 ± 0.51^a^c
CPHT+anti-rat TNFα	0.39 ± 0.08^a	0.138 ± 0.029^a	1.53 ± 0.13^a	20.75 ± 1.92^a	24.15 ± 1.67^a	5.56 ± 0.59^a	5.21 ± 0.51^a
cPHT+L-NMMA	0.32 ± 0.02^a	0.076 ± 0.005^e	1.12 ± 0.08^e	12.75 ± 0.82^a^e	16.08 ± 0.74^a^e	10.13 ± 0.26^a^e	8.84 ± 0.66^a^e
PVL72 h	0.42 ± 0.03^a^g	0.143 ± 0.029^a^g	2.38 ± 0.05^a^g	23.27 ± 1..52^a^g	25.43 ± 1.44^a^g	4.44 ± 0.28^a^g	4.54 ± 0.32^a^g
PVL72 h+anti-rat TNFα	0.33 ± 0.02^a	0.127 ± 0.008^a	1.68 ± 0.12^a	19.3 ± 1.1^a	20.7 ± 2^a	5.9 ± 0.1^a	6.0 ± 0.5^a
PVL72 h+L-NMMA	0.24 ± 0.04ⁱ	0.072 ± 0.013ⁱ	0.85 ± 0.15ⁱ	9.82 ± 0.96ⁱ	10.77 ± 1.11ⁱ	12.58 ± 0.93ⁱ	12.42 ± 0.99ⁱ

^aP < 0.05 vs control,

^cP < 0.05 cPHT group compared with cPHT+anti-rat TNFα and cPHT+L-NMMA groups respectively,

^eP < 0.05 cPHT+anti-rat TNFα compared with cPHT+L-NMMA groups,

^gP < 0.05 PVL 72 h group compared with PVL 72 h+anti-rat TNFα and PVL 72 h+L-NMMA groups respectively,

ⁱP < 0.05 PVL 72 h+anti-rat TNFα compared with PVL 72 h+L-NMMA.

Citation: Wang JJ, Gao GW, Gao RZ, Liu CA, Ding X, Yao ZX. Effects of tumor necrosis factor, endothelin and nitric oxide on hyperdynamic circulation of rats with acute and chronic portal hypertension. World J Gastroenterol 2004; 10(5): 689-693
URL: https://www.wjgnet.com/1007-9327/full/v10/i5/689.htm
DOI: https://dx.doi.org/10.3748/wjg.v10.i5.689