Effect of arsenic trioxide on human hepatocarcinoma in nude mice

Table 1 Inhibitory action of arsenic trioxide on tumor mass (mean ± SD)

Groups	Number	Volume d 1	Volume d 5	Volume d 10	Mouse mass (g)	Inhibitory rate (%) 5th d	Inhibitory rate (%) 10th d
Saline	10	0.123 ± 0.052	0.234 ± 0.072	0.415 ± 0.084	23.07 ± 3.14
5-Fu	10	0.113 ± 0.060	0.134 ± 0.040	14.07 ± 2.29		86.85
As203 (2.5 mg/kg)	10	0.102 ± 0.041	0.218 ± 0.099	0.238 ± 0.043b	20.50 ± 1.95		53.42
As203 (5 mg/kg)	10	0.098 ± 0.030	0.121 ± 0.038	0.103 ± 0.042b	20.28 ± 1.63	79.28	96.58

^bP < 0.01 vs saline group.

Table 2 Routine blood examination results (mean ± SD)

Groups	Number	WBC (× 1010/L)	Hgb (g/L)	PLT (× 109/L)
Saline	10	1.05 ± 0.12	140.24 ± 13.21	221.65 ± 70.34
As203 (2.5 mg/kg)	10	1.13 ± 0.16	138.67 ± 13.17	231.75 ± 68.48
As203 (5 mg/kg)	10	1.21 ± 0.16	142.58 ± 15.29	246.38 ± 60.45

Table 3 Expression of AFP protein (mean ± SD)

Group	Number	AFP (%)
Saline	10	48.32 ± 4.56
As203 (2.5 mg/kg)	10	29.78 ± 3.10b
As203 (5 mg/kg)	10	22.26 ± 2.31b

^bP < 0.01 vs saline group.