Copyright
©The Author(s) 2004.
World J Gastroenterol. Dec 15, 2004; 10(24): 3639-3642
Published online Dec 15, 2004. doi: 10.3748/wjg.v10.i24.3639
Published online Dec 15, 2004. doi: 10.3748/wjg.v10.i24.3639
Table 1 Levels of MCP-1, sICAM-1, sP-selectin, IL-6 and IL-10 in patients with chronic hepatitis C during IFN + RBV therapy in responders (R) and non-responders (NR)
0-wk | 16-wk | 32-wk | 48-wk | Control | ||
sICAM-1 (pg/mL) | NR | 434 ± 104ab | 372 ± 111ab | 404 ± 87b | 389 ± 77b | 230 ± 29 |
R | 527 ± 109ab | 433 ± 87ab | 353 ± 98b | 363 ± 99 | ||
sP-selectin (pg/mL) | NR | 240 ± 101ab | 137 ± 47 | 145 ± 33 | 147 ± 41 | 144 ± 75 |
R | 144 ± 57a | 131 ± 68 | 131 ± 58 | 23 ± 47 | ||
MCP-1 (pg/mL) | NR | 290 ± 91 | 365 ± 124ab | 315 ± 61 | 325 ± 50a | 268 ± 109 |
R | 281 ± 84 | 285 ± 55a | 335 ± 32b | 286 ± 59a | ||
IL10 (pg/mL) | NR | 0.45 ± 0.46a | 0.81 ± 0.54 | 0.77 ± 0.68 | 0.9 ± 0.63 | 0.62 ± 0.83 |
R | 0.88 ± 0.78a | 0.89 ± 0.74 | 0.69 ± 0.73 | 1.01 ± 0.77 | ||
IL6 (pg/mL) | NR | 0.65 ± 0.61ab | 2.21 ± 0.94ab | 1.07 ± 1.68b | 1.56 ± 1.32b | 0.22 ± 0.49 |
R | 0.16 ± 0.37ab | 0.76 ± 0.69ab | 0.77 ± 0.55b | 1.05 ± 1.21b | ||
ALT (IU/mL) | NR | 82 ± 40 | 26 ± 17 | 23 ± 10 | 61 ± 91 | 32 ± 6 |
R | 60 ± 30 | 21 ± 6 | 24 ± 6 | 22 ± 6 | ||
Prothrombin index (%) | NR | 96 ± 23 | 97 ± 6 | 98 ± 11 | 99 ± 10 | 98 ± 6 |
R | 5 ± 7 | 90 ± 10 | 83 ± 13 | 90 ± 7 | ||
Blood platelet (G/L) | NR | 196 ± 21 | 189 ± 45 | 190 ± 52 | 179 ± 51 | 203 ± 45 |
R | 196 ± 21 | 189 ± 45 | 190 ± 52 | 17 ± 51 |
Table 2 Correlation of adhesion molecules, cytokines and MCP-1 levels with liver histopathology in responders (R) and non-responders (NR)
Grading (inflammation) | |||||||
Periportal | Intralobular | Staging (fibrosis) | |||||
R | NR | R | NR | R | NR | ||
sICAM-1 | r | N | 0.36 | 0.38 | 0.56 | N | 0.32 |
P | N | < 0.05 | < 0.05 | < 0.01 | N | < 0.05 | |
MCP-1 | r | 0.35 | N | N | N | N | N |
P | < 0.05 | N | N | N | N | N | |
IL-6 | r | N | N | 0.53 | N | N | 0.38 |
P | N | N | < 0.01 | N | N | < 0.05 | |
IL-10 | r | N | N | N | N | N | N |
P | N | N | N | N | N | N | |
sP-selectin | r | N | N | N | N | N | N |
P | N | N | N | N | N | N |
- Citation: Panasiuk A, Prokopowicz D, Panasiuk B. Monocyte chemotactic protein-1 and soluble adhesion molecules as possible prognostic markers of the efficacy of antiviral treatment in chronic hepatitis C. World J Gastroenterol 2004; 10(24): 3639-3642
- URL: https://www.wjgnet.com/1007-9327/full/v10/i24/3639.htm
- DOI: https://dx.doi.org/10.3748/wjg.v10.i24.3639