Scintigraphic detection of carcinoid tumors with a cost effectiveness analysis

Table 1 Characteristics of patients enrolled in study

Pt	Sex	Age (yr)	Primary tumor site	Metastases	Carcinoid syndrome related signs and symptoms	SRS primary metastases sites		Conventional imaging methods primary metastases sites
Patients with confirmed tumors
1	F	69	Stomach			-	-	-	-
2	M	58	Stomach			+	-	-	-
3	M	55	Duodenum			-	-	-	-
4	M	55	Small intestine	Liver		+	+	-	+
5	F	69	Small intestine			+	-	-	-
6	M	33	Appendix	Lymph nodes		+	+	-	-
7	F	27	Appendix			-	-	-	-
8	M	39	Appendix	Liver-ribs	Diarrhoea	+	+	+	+
9	M	59	Caecum			-	-	+	-
10	F	64	Caecum			+	-	-	-
11	M	69	Rectum			+	-	-	-
12	F	57	Rectum			+	-	-	-
13	F	49	Pancreas	Liver-lung	Diarrhoea	+	+	+	+
14	M	58	Pancreas	Liver-lymph nodes	Diarrhoea flushes	+	+	+	+
Patients previously operated
15	F	42	Stomach	Liver			+		+
16	M	34	Appendix	Liver			-		+
17	M	36	Appendix	Lymph nodes			+		+
18	F	40	Appendix	Liver-Lymph nodes			+		+
19	M	69	Small intestine	Lymph nodes			+		+
20	M	61	Small intestine	Liver			+		+
21	F	67	Caecum	Lymph nodes			+		+
22	F	56	Colon Liver				-		+
23	M	72	Rectum	Liver-lymph nodes			-		+
24	M	59	Pancreas	Liver			-		+
Patients with suspected carcinoid tumors
25	M	34	Appendix		Flushes	-	-	-	-
26	F	33	Appendix		Diarrhoea	+	-	-	-
27	M	51	Small intestine	Liver	Diarrhoea flushes	-	+	-	-
28	M	62	Caecum		Diarrhoea	+	-	+	-
29	M	61	Caecum	Liver-lymph nodes	Diarrhoe flushes	+	+	+	-
30	F	71	Caecum	Liver	Diarrhoea flushes	+	+	+	+
31	F	73	Pancreas	Liver-lungs	Diarrhoea flushes	+	+	+	+

Table 2 False-negative results of SRS and conventional imaging methods for primary sites

Method	Detection of carcinoids		Patient No	False-negative (%)
SRS	Known carcinoids	4/14 patients	1, 3, 7, 9	28.57
	Suspected carcinoids	2/7 patients	25, 27	28.57
Conventional	Known carcinoids	10/14 patients	1-7, 10-12	71.42
imaging methods	Suspected carcinoids	3/7 patients	25, 26, 27	42.85

Table 3 False-negative results of SRS and conventional imaging methods for metastatic sites

Method	Detection of carcinoids		Patient No	False-negative (%)
SRS	Known carcinoids	4/24 patients	16, 22-24	16.66
	Suspected carcinoids	0/7 patients	-	0
Conventional	Known carcinoids	1/24 patients	6	4.16
imaging methods	Suspected carcinoids	2/7 patients	27, 29	28.6

Table 4 Cost in Euro of used techniques

Chest X-ray	3.29
Upper abdominal	8.22
ultrasonography
Chest CT-scan	71.11
Upper abdominal CT-scan	71.11
	48.11	• for the contrast liquid
Lower abdominal CT-scan	71.11
SRS	1172.42