Gastroprotective effect and mechanism of amtolmetin guacyl in mice

Table 1 Influence of AMG on NO and NOS contents in stom-ach homogenates in ethanol-induced gastric mucosal damage models (n = 10, mean ± SD)

Group	n	Dose (mg/kg)	NO2- (μmol/mgprot)	NOS (U/mgprot)
Normal	10	-	60.57 ± 22.11b	4.22 ± 0.92b
Model	10	-	33.08 ± 12.85	2.41 ± 0.56
TOL	10	90	46.46 ± 12.69	3.27 ± 0.68
AMG	10	300	70.37 ± 27.97b	5.25 ± 1.62b
	10	150	58.65 ± 17.11a	4.12 ± 1.02a
	10	75	30.98 ± 11.97	3.47 ± 1.17a

^aP < 0.05,

^bP < 0.01, vs Model.

Table 2 Influence of AMG on SOD, MDA contents in stomach homogenates in ethanol-induced gastric mucosal damage models (n =10, mean ± SD)

Group	n	Dose (mg/kg)	SOD (U/mgprot)	MDA (nmol/mgprot)
Normal	10	-	702.61 ± 144.77b	2.85 ± 1.32b
Model	10	-	551.94 ± 125.94	4.18 ± 1.19
TOL	10	90	526.14 ± 110.80	5.07 ± 2.09
AMG	10	300	624.97 ± 117.19a	3.13 ± 1.35a
	10	150	612.06 ± 101.90a	3.46 ± 1.21a
	10	75	606.13 ± 65.81	3.57 ± 1.05

^aP < 0.05,

^bP < 0.01, vs Model.