Involvement of extracellular signal-regulated kinase/mitogen-activated protein kinase pathway in multidrug resistance induced by HBx in hepatoma cell line

Table 1 Protein level of MDR associated genes (mean ± SD)

Group	MDR-1	MRP-1	LRP
transfected	0.23 ± 0.04	0.15 ± 0.03	0.17 ± 0.03
control	0.14 ± 0.03	0.08 ± 0.03	0.09 ± 0.02
P	0.036	0.046	0.018

Table 2 mRNA level of MDR associated genes (mean ± SD)

Group	MDR-1	MRP-1	LRP
Transfected	0.29 ± 0.06	0.62 ± 0.11	0.82 ± 0.15
Control	0.10 ± 0.03	0.37 ± 0.09	0.42 ± 0.07
P	0.038	0.012	0.014

Table 3 Changes of MDR related genes after treated with U0126 (mean ± SD)

Group	MDR-1	MRP-1	LRP
Transfected	0.15 ± 0.03	0.62 ± 0.11	0.78 ± 0.13
Treated with U0126	0.08 ± 0.02	0.37 ± 0.09	0.44 ± 0.09
P	0.028	0.040	0.020

Table 4 Changes of MDR related proteins after treated with U0126 (mean ± SD)

Group	MDR-1	MRP-1	LRP
Transfected	0.22 ± 0.04	0.17 ± 0.02	0.14 ± 0.02
Treated with U0126	0.13 ± 0.04	0.12 ± 0.02	0.09 ± 0.02
P	0.04	0.038	0.04