Genomic determination of CR1 CD35 density polymorphism on erythrocytes of patients with gallbladder carcinoma

Table 1 The number and adhering activity of CR1 in different groups before operation (mean ± SE)

Group	Cases	CR1 (A405)	Adhering activity (%)
Healthy individuals	30	1.252 ± 0.31	64.2 ± 7.4
Chronic cholecystitis	90	1.078±0.21a	55.1±5.9a
Cholecystolithiasis
Gallbladder carcinoma	33	0.738 ± 0.23bc	45.9 ± 5.7bd

^aP < 0.05,

^bP < 0.01 vs normal control;

^cP < 0.05,

^dP < 0.01 vs chronic cholecystitis and cholecystolithiasis.

Table 2 The number and adhering activity of CR1 in different groups before operation (mean ± SE)

Group	Cases	CR1(A405)	Adhering activity (%)
Healthy individuals	30	1.252 ± 0.31	64.2 ± 7.4
cholecystolithiasis	46	1.027 ± 0.27a	54.4 ± 5.9a
Gallbladder carcinoma	18	0.731 ± 0.26bc	45.1 ± 6.1bd
with cholecystolithiasis
Simple gallbladder carcinoma	15	0.728 ± 0.23bc	44.8 ± 6.4bd

^aP < 0.05,

^bP < 0.01 vs normal control;

^cP < 0.05,

^dP < 0.01 vs chronic cholecystitis.

Table 3 The number and adhering activity of CR1 in different groups before operation (mean ± SE)

Type	Cases	CR1(A405)	Adhering activity (%)
Simple hyperplasia	59	1.175 ± 0.22	61.1 ± 6.2
Atypical hyperplasia	21	0.906 ± 0.24b	50.8 ± 5.7b
Gallbladder carcinoma	23	0.761 ± 0.23b	41.6 ± 6.1b
(I-III stage)
Gallbladder carcinoma	10	0.602 ± 0.31b	30.4 ± 6.5b
(IV-V stage)
F		6.4	11.5
P		< 0.01	< 0.01

^bP < 0.01 vs each group.

Table 4 The number and adhering activity of CR1 on preoperative and postoperative day (mean ± SE)

Group	Preoperative	3rd d	1st wk	2nd wk	3rd wk
CR1 (A405)	0.738 ± 0.23	0.310 ± 0.25b	0.480 ± 0.25b	0.740 ± 0.24	0.85 ± 0.32a
Adhering activity (%)	45.4 ± 4.9	31.8 ± 5.1b	38.9 ± 5.2b	46.8 ± 5.9	52.7 ± 5.8a

^aP < 0.05,

^bP < 0.01 vs normal control.

Table 5 The number and adhering activity of CR1 in gallbladder carcinoma with adjacent lymph nodes and metastasis (mean ± SE)

Group	Healthy individuals	Infiltrating (-)	Infiltrating (+)	Adjacent lymph node (-)	Adjacent lymph node (+)	Metastasis (-)	Metastasis (+)
Cases	30	15	18	18	15	23	10
CR1 (A405)	1.252 ± 0.31	0.95 ± 0.22a	0.81 ± 0.29ab	0.88 ± 0.27a	0.73 ± 0.25ab	0.78 ± 0.26a	0.44 ± 0.29ad
Adhering activity (%)	64.2 ± 7.4	52.8 ± 6.7a	48.1 ± 7.2ab	47.6 ± 7.0a	41.1 ± 7.1ab	46.1 ± 6.1a	38.9 ± 6.2ad

^bP < 0.01 vs normal control;

^aP < 0.05,

^dP < 0.01 vs negative.