Insulin is necessary for the hypertrophic effect of cholecystokinin-octapeptide following acute necrotizing experimental pancreatitis

Table 1 Laboratory parameters changes in diabetic-pancreatitic rats due to a 14 d administration of insulin and/or CCK-8

	Serum glucose	Serum insulin	pm/bm	Pancreatic DNA	Pancreatic protein	Pancreatic amylase	Pancreatic trypsinogen	pancreatic lipase
Insulin treatment	↓	↑	↑	-	-	↑	-	-
CCK-8 treatment	-	-	-	-	-	-	-	-
Insulin and CCK-8 treatment	↓	↑	↑	-	↑	↑↑	↑	-

CCK-8: cholecystokinin-octapeptide, pm/bm: pancreatic weight/body weight ratio. ↑ increased or ↓ decreased activity/ level, – no change, ↑↑ significantly larger increase of activity compared with the ↑ sign. All changes are given in comparison to the untreated diabetic-pancreatitic rats (group DP).