Role of COX-2 in microcirculatory disturbance in experimental pancreatitis

Table 1 Levels of amylase (AMS) and myeloperoxidase (MPO) in AEP and control groups (mean ± SD)

Group	n	MPO (U/mL)	AMS (U/dL)
Control (0 h)	24	0.32 ± 0.13	40 ± 37
AEP 2nd h	6	0.60 ± 0.20	313 ± 130a
4th h	6	0.74 ± 0.39b	391 ± 96a
8th h	6	0.85 ± 0.56b	255 ± 92a
16th h	6	0.88 ± 0.29b	291 ± 73a
F		4.542	12.322

^aP < 0.05, ^bP < 0.01 vs control.

Table 2 Response of pancreatic local microvascular in AEP and controls (mean ± SD)

	4th h		6th h		8th h
	NC	AIP	NC	AIP	NC	AIP
1Density of RBC/(± 109cell/L)	113 ± 5	85 ± 9a	104 ± 4	68 ± 7a	96 ± 6	59 ± 9a
2Velocity of RBC/(cell/min)	86 ± 3	43 ± 2a	81 ± 4	36 ± 5a	84 ± 5	30 ± 5a
3RBC flow (nL/L)	0.28 ± 0.01	0.12 ± 0.03a	0.31 ± 0.02	0.09 ± 0.03a	0.29 ± 0.04	0.07 ± 0.03a
4Blood flow	0.88 ± 0.06	0.56 ± 0.09a	0.99 ± 0.07	0.45 ± 0.12a	0.91 ± 0.06	0.34 ± 0.10a
5Diameter (arteriod)/μm	23.5 ± 8.0	20.2 ± 5.1a	24.1 ± 8.0	16.4 ± 3.1a	23.2 ± 5.5	18.2 ± 3.5a
6Diameter (venule)/μm	28 ± 3.0	29.1 ± 2.0a	28 ± 2.7	27.5 ± 3.0a	27.4 ± 1.6	29 ± 1.5a
7Diameter (capillary)/μm	6.7 ± 1.5	7.0 ± 1.4a	6.9 ± 1.5	6.0 ± 0.3a	7.3 ± 1.0	5.2 ± 0.3a
8Density (capillary)/cm	394 ± 7	381 ± 9a	400 ± 6	291 ± 16a	349 ± 8	277 ± 13a

¹F = 109.68, P < 0.01;

²F = 478.8, P < 0.01;

³F = 185.2, P < 0.01;

⁴F = 1.99, P < 0.01;

⁵F = 3.52, P < 0.001;

⁶F = 1.12, P > 0.05;

⁷F = 5.71, P < 0.001;

⁸F = 312.12, P < 0.01;

^aP < 0.05 vs control.