Influence of serum collected from rat perfused with compound Biejiaruangan drug on hepatic stellate cells

doi:10.3748/wjg.v10.i10.1487

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 10, Issue 10

This Article

Citation of this article

Corresponding Author of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (3100)

All Articles published online

The chart showing PDF series, HTML series, Figures (1-6) series, Tables (1-9) series.

Item

Count

PDF

273

HTML

2516

Figures (1-6)

167

Tables (1-9)

144

Sum=3100

May 15, 2004 (publication date) through Jul 22, 2024

Times Cited of This Article

Times Cited (15)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Basic Research

World J Gastroenterol. May 15, 2004; 10(10): 1487-1494
Published online May 15, 2004. doi: 10.3748/wjg.v10.i10.1487

Table 1 Influence of each group serum on proliferation of HSC at different time points (A value: mean ± SD)

	N	M	G	Z	D
24 h	0.40 ± 0.06	0.40 ± 0.03	0.38 ± 0.03	0.391 ± 0.02	0.38 ± 0.03
48 h	0.52 ± 0.03^c	0.66 ± 0.05^a	0.47 ± 0.02^a^c	0.460 ± 0.02^a^c	0.51 ± 0.03^c
72 h	0.75 ± 0.09^c	0.96 ± 0.05^a	0.55 ± 0.07^a^c	0.580 ± 0.08^a^c	0.69 ± 0.07^c

N: Control group; M: Model group; G: High dosage group; Z: Medium dosage group; D: Low dosage group,

^aP < 0.05 vs normal group;

^cP < 0.05 vs model group.

Table 2 Influence of each group serum on α-SMA of HSC at different time points (A value: mean ± SD)

	N		M		G		Z		D
	A	Male cell area (%)	A	Male cell area (%)	A	Male cell area (%)	A	Male cell area (%)	A	Male cell area (%)
24 h	619.89 ± 163.84^c	7.49 ± 2.06^c	778.93 ± 190.26^a	9.64 ± 0.26^a	110.95 ± 45.21^a^c	0.90 ± 0.22^a^c	243.83 ± 62.97^a^c	2.72 ± 1.48^a^c	417.46 ± 126.72^c	3.56 ± 0.91^c
48 h	812.51 ± 123.39^c	8.28 ± 4.58^c	1032.69 ± 106.64^a	10.56 ± 1.83^a	333.71 ± 57.9^a^c	1.55 ± 0.29^a^c	345.08 ± 51.85^a^c	3.66 ± 1.67^a^c	675.35 ± 202.20^c	5.45 ± 2.50^c
72 h	989.77 ± 166.32^c	9.36 ± 2.39^c	1255.30 ± 150.39^a	15.66 ± 2.34^a	448.36 ± 55.80^a^c	3.25 ± 0.56^a^c	556.27 ± 80.32^a^c	4.66 ± 1.24^a^c	759.38 ± 109.32^a^c	6.99 ± 1.58^a^c

N: Control group; M: Model group; G: High dosage group; Z: Medium dosage group; D: Low dosage group,

^aP < 0.05 vs normal group;

^cP < 0.05 vs model group.

Table 3 Influence of each group serum on desmin of HSC at different time points (A value: mean ± SD)

	N		M		G		Z		D
	A	Male cell area (%)	A	Male cell area (%)	A	Male cell area (%)	A	Male cell area (%)	A	Male cell area (%)
24 h	78.93 ± 18.56^c	17.49 ± 2.06^c	119.69 ± 23.84^a	20.64 ± 2.26^a	58.95 ± 5.21^a^c	12.90 ± 3.22^a^c	63.83 ± 12.97^a^c	12.72 ± 1.48^a^c	75.46 ± 26.72^c	13.56 ± 0.91^c
48 h	103.78 ± 36.64^c	10.28 ± 4.58^c	182.51 ± 28.43^a	14.56 ± 1.83^a	63.71 ± 7.94^a^c	8.55 ± 0.29^a^c	65.08 ± 18.85^a^c	7.66 ± 1.67^a^c	79.35 ± 22.28^c	9.35 ± 2.50^c
72 h	125.30 ± 40.39^c	9.36 ± 2.39^c	1255.30 ± 150.39^a	15.66 ± 2.34^a	448.36 ± 55.80^a^c	3.25 ± 0.56^a^c	556.27 ± 80.32^a^c	4.66 ± 1.24^a^c	759.38 ± 109.32^a^c	6.99 ± 1.58^a^c

N: Control group; M: Model group; G: High dosage group; Z: Medium dosage group; D: Low dosage group,

^aP < 0.05 vs normal group;

^cP < 0.05 vs model group.

Table 4 Influence of each group serum on synapsin of HSC at different time points (A value: mean ± SD)

	N		M		G		Z		D
	A	Male cell area (%)	A	Male cell area (%)	A	Male cell area (%)	A	Male cell area (%)	A	Male cell area (%)
24 h	396.29 ± 78.56^c	5.49 ± 2.06^c	528.79 ± 26.84^c	12.93 ± 2.33^c	138.92 ± 20.21^a^c	2.64 ± 0.22^a^c	190.87 ± 52.97^a^c	3.69 ± 1.24^a^c	284.54 ± 66.72^c	4.05 ± 0.91^c
48 h	577.78 ± 86.84^c	8.28 ± 4.58^c	748.57 ± 29.73^c	10.56 ± 1.83^c	228.71 ± 71.94^a^c	1.55 ± 0.29^a^c	338.08 ± 108.66^a^c	3.66 ± 1.67^a^c	675.35 ± 202.20^c	5.45 ± 2.50^c
72 h	989.77 ± 166.32^c	9.36 ± 2.39^c	1255.30 ± 150.39^c	15.66 ± 2.34^c	448.36 ± 55.80^a^c	3.25 ± 0.56^a^c	556.27 ± 80.32^a^c	4.66 ± 1.24^a^c	759.38 ± 109.32^a^c	6.99 ± 1.58^a^c

N: Control group; M: Model group; G: High dosage group; Z: Medium dosage group; D: Low dosage group,

^aP < 0.05 vs normal group;

^cP < 0.05 vs model group.

Table 5 Influence of each group serum on collagen I of HSC at different time points (A value: mean ± SD)

	N		M		G		Z		D
	A	Male cell area (%)	A	Male cell area (%)	A	Male cell area (%)	A	Male cell area (%)	A	Male cell area (%)
24 h	50.87 ± 9.84	5.49 ± 2.06^c	60.63 ± 9.26	4.64 ± 0.26	46.95 ± 5.21	2.90 ± 0.22	44.83 ± 6.97	3.72 ± 0.48	49.46 ± 7.36	3.89 ± 0.79
48 h	270.51 ± 13.56	5.28 ± 0.58	456.78 ± 106.64	5.56 ± 1.83	107.79 ± 17.9	4.45 ± 0.29	115.28 ± 51.85	4.66 ± 1.67	129.35 ± 22.20	4.45 ± 0.50
72 h	507.77 ± 66.38^c	11.36 ± 2.39^c	800.30 ± 150.39^a	15.66 ± 2.34^a	300.23 ± 25.80^a^c	5.25 ± 0.56^a^c	329.37 ± 45.98^a^c	6.62 ± 1.33^a^c	425.38 ± 19.32^c	7.99 ± 1.25^c

N: Control group; M: Model group; G: High dosage group; Z: Mdium dosage group; D: Low dosage group,

^aP < 0.05 vs normal group;

^cP < 0.05 vs model group.

Table 6 Influence of each group serum on collagen III of HSC at different time points (A value: mean ± SD)

	N		M		G		Z		D
	A	Male cell area (%)	A	Male cell area (%)	A	Male cell area (%)	A	Male cell area (%)	A	Male cell area (%)
24 h	60.93 ± 18.56	12.49 ± 3.16	65.69 ± 23.841	3.64 ± 2.36	40.95 ± 5.21	8.90 ± 3.82	45.83 ± 12.97	9.72 ± 1.47	52.46 ± 26.72	10.56 ± 0.56
48 h	203.78 ± 36.64^c	25.28 ± 4.27^c	282.51 ± 28.43^a	31.56 ± 3.69^a	63.71 ± 7.94^a^c	15.55 ± 3.59^a^c	65.08 ± 18.85^a^c	17.66 ± 1.65^a^c	79.35 ± 22.28^a^c	21.35 ± 2.36^a^c
72 h	325.30 ± 40.39^c	30.36 ± 2.50^c	501.77 ± 56.42^a	40.66 ± 4.82^a	178.36 ± 5.82^a^c	23.25 ± 4.26^a^c	182.27 ± 20.32^a^c	25.66 ± 1.29^a^c	220.38 ± 19.32^c	29.70 ± 1.72^c

N: Control group; M: Model group; G: High dosage group; Z: Medium dosage group; D: Low dosage group,

^aP < 0.05 vs normal group;

^cP < 0.05 vs model group.

Table 7 Influence of each group serum on TIMP of HSC at different time points (A value: mean ± SD)

	N		M		G		Z		D
	A	Male cell area (%)	A	Male cell area (%)	A	Male cell area (%)	A	Male cell area (%)	A	Male cell area (%)
24 h	60.93 ± 18.56	12.49 ± 3.16	65.69 ± 23.84	13.64 ± 2.36	40.95 ± 5.21	8.90 ± 3.82	45.83 ± 12.97	9.72 ± 1.47	52.46 ± 26.72	10.56 ± 0.56
48 h	203.78 ± 36.64^c	25.28 ± 4.27^c	282.51 ± 28.43^a	31.56 ± 3.69^a	63.71 ± 7.94^a^c	15.55 ± 3.59^a^c	65.08 ± 18.85^a^c	17.66 ± 1.65^a^c	79.35 ± 22.28^a^c	21.35 ± 2.36^a^c
72 h	325.30 ± 40.39^c	30.36 ± 2.50^c	501.77 ± 56.42^a	40.66 ± 4.82^a	178.36 ± 5.82^a^c	23.25 ± 4.26^a^c	182.27 ± 20.32^a^c	25.66 ± 1.29^a^c	220.38 ± 19.32^c	29.70 ± 1.72^c

N: Control group; M: Model group; G: High dosage group; Z: Medium dosage group; D: Low dosage group,

^aP < 0.05 vs normal group;

^cP < 0.05 vs model group.

Table 8 Influence of each group serum on TGFβ1 of HSC at different time points (A value: mean ± SD)

	N		M		G		Z		D
	A	Male cell area (%)	A	Male cell area (%)	A	Male cell area (%)	A	Male cell area (%)	A	Male cell area (%)
24 h	126.56 ± 21.69	5.14 ± 0.69	158.79 ± 27.63	9.67 ± 2.59	98.92 ± 29.25	5.48 ± 0.49	105.69 ± 27.96	6.72 ± 1.74	122.56 ± 67.84	6.21 ± 0.98
48 h	570.78 ± 57.61^c	15.78 ± 0.78^c	733.58 ± 189.73^a	19.39 ± 3.76^a	428.71 ± 51.30^a^c	7.36 ± 0.87^a^c	458.08 ± 37.98^a^c	9.87 ± 1.98^a^c	549.35 ± 124.29^c	13.27 ± 2.77^a
72 h	1279.30 ± 147.78^c	21.98 ± 2.38^c	1509.87 ± 77.50^a	27.58 ± 5.65^a	609.37 ± 72.85^a^c	9.25 ± 0.67^a^c	823.75 ± 158.49^a^c	12.35 ± 1.75^a^c	971.57 ± 127.83^c	19.30 ± 1.36^c

N: Control group; M: Model group; G: High dosage group; Z: Medium dosage group; D: Low dosage group,

^aP < 0.05 vs normal group;

^cP < 0.05 vs model group.

Table 9 Influence of each group serum on PDGF of HSC at different time points (A value: mean ± SD)

	N		M		G		Z		D
	A	Male cell area (%)	A	Male cell area (%)	A	Male cell area (%)	A	Male cell area (%)	A	Male cell area (%)
24 h	326.47 ± 15.31^c	7.14 ± 0.69	447.69 ± 25.47^a	12.05 ± 3.87	128.87 ± 35.14^a^c	4.21 ± 0.29	187.39 ± 36.67^a^c	7.83 ± 0.67	227.87 ± 54.39^c	9.64 ± 0.87
48 h	479.65 ± 38.49^c	24.78 ± 5.90^c	659.45 ± 76.56^a	37.25 ± 4.89^c	214.17 ± 54.67^a^c	9.28 ± 0.70^a^c	264.58 ± 49.57^a^c	14.02 ± 2.06^a^c	379.27 ± 75.02^c	18.56 ± 3.27^a^c
72 h	805.30 ± 121.04^c	32.98 ± 5.49^c	1208.02 ± 132.21^a	45.94 ± 5.37^c	427.21 ± 39.72^a^c	15.07 ± 2.78^a^c	560.41 ± 132.02^a^c	19.28 ± 2.09^a^c	720.34 ± 102.07^c	27.19 ± 3.29^a^c

N: Control group; M: Model group; G: High dosage group; Z: Medium dosage group; D: Low dosage group,

^aP < 0.05 vs normal group;

^cP < 0.05 vs model group.

Citation: Guo SG, Zhang W, Jiang T, Dai M, Zhang LF, Meng YC, Zhao LY, Niu JZ. Influence of serum collected from rat perfused with compound Biejiaruangan drug on hepatic stellate cells. World J Gastroenterol 2004; 10(10): 1487-1494
URL: https://www.wjgnet.com/1007-9327/full/v10/i10/1487.htm
DOI: https://dx.doi.org/10.3748/wjg.v10.i10.1487