Copyright
©The Author(s) 2004.
World J Gastroenterol. May 15, 2004; 10(10): 1457-1461
Published online May 15, 2004. doi: 10.3748/wjg.v10.i10.1457
Published online May 15, 2004. doi: 10.3748/wjg.v10.i10.1457
Table 1 Macrophage phagocytosis in diabetic mice after pig islet xenotransplantation
Group | Pre-treatment | 7 d post-treatment | 14 d post-treatment | |||
Percent (%) | Index | Percent (%) | Index | Percent (%) | Index | |
Hepatocytes group | 59.3 ± 4.5 | 1.05 ± 0.04 | 62.8 ± 4.37 | 1.28 ± 0.13 | 70.6 ± 3.82 | 1.25 ± 0.07 |
Splenocytes group | 62.5 ± 3.0 | 1.04 ± 0.07 | 63.1 ± 6.45 | 1.18 ± 0.14 | 69.5 ± 3.62 | 1.21 ± 0.09 |
Mixture group | 63.1 ± 3.8 | 1.07 ± 0.06 | 61.6 ± 3.54 | 1.12 ± 0.09 | 62.8 ± 4.70 | 1.09 ± 0.08 |
Islet group | 62.0 ± 3.3 | 1.06 ± 0.08 | 73.5 ± 5.51 | 1.41 ± 0.18 | 72.7 ± 5.71 | 1.47 ± 0.10 |
Table 2 Effect of transplantation with pig islets on splenic lymphocyte transforming function in mice
Group | Pre-transplantation (cpm) | 7 d post-transplantation (cpm) | 14 d post-transplantation (cpm) |
Hepatocytes group | 11437.56 ± 1137.55 | 23453.74 ± 4157.28 | 20178.56 ± 4159.74 |
Splenocytes group | 11437.56 ± 1137.55 | 25834.66 ± 3763.37 | 15336.25 ± 3782.38 |
Mixture group | 11437.56 ± 1137.55 | 21920.05 ± 600.08 | 14345.53 ± 2653.28 |
Islets group | 11437.56 ± 1137.55 | 32339.13 ± 5071.67 | 22182.16 ± 750.28 |
Table 3 Effect of pig islet xenotransplantation on NK activity (%) in diabetic mice
Group | Pre-treatment | 7 d post-treatment | 14 d post-treatment |
Hepatocytes group | 31.56 ± 4.23 | 63.17 ± 3.47 | 60.26 ± 7.65 |
Splenocytes group | 31.76 ± 3.48 | 62.50 ± 4.86 | 56.19 ± 8.13 |
Mixture group | 31.37 ± 8.09 | 48.00 ± 12.0 | 34.33 ± 14.57 |
Islet group | 35.67 ± 3.51 | 76.23 ± 12.50 | 71.00 ± 3.0 |
Table 4 Variations of T lymphocytes in diabetic mice after pig islet xenotransplantation
Group | Pretreatment(%) | 7 d post-treatment (%) | 14 d post-treatment (%) | ||||||
CD3 | CD4 | CD8 | CD3 | CD4 | CD8 | CD3 | CD4 | CD8 | |
Hepatocyte group | 61.6 ± 4.5 | 42.0 ± 4.6 | 24.3 ± 1.5 | 72.7 ± 5.5 | 51.6 ± 4.5 | 28.0 ± 3.6 | 70.0 ± 2.0 | 52.7 ± 4.9 | 26.7 ± 4.2 |
Splenocyte group | 66.0 ± 3.6 | 46.3 ± 4.0 | 24.6 ± 2.5 | 73.0 ± 4.4 | 53.3 ± 4.5 | 31.3 ± 4.1 | 68.7 ± 5.7 | 45.3 ± 4.1 | 33.0 ± 3.6 |
Mixture group | 64.7 ± 2.5 | 44.3 ± 6.7 | 25.3 ± 4.9 | 65.0 ± 5.3 | 47.6 ± 3.8 | 28.3 ± 2.5 | 61.6 ± 3.5 | 47.0 ± 4.4 | 27.7 ± 2.1 |
Islet group | 65.0 ± 7.0 | 43.3 ± 3.0 | 24.3 ± 3.2 | 80.0 ± 2.0 | 60.6 ± 3.2 | 32.3 ± 3.1 | 72.3 ± 6.7 | 58.7 ± 9.1 | 32.0 ± 4.0 |
Table 5 B lymphocyte antibody-forming function (A value) in mice after transplantation (A)
Group | Pretransplantation | 7 d post-transplantation | 14 d post-transplantation |
Hepatocyte group | 0.34 ± 0.06 | 0.44 ± 0.02 | 0.63 ± 0.07 |
Splenocyte group | 0.34 ± 0.06 | 0.55 ± 0.02 | 0.63 ± 0.08 |
Mixture group | 0.34 ± 0.06 | 0.55 ± 0.01 | 0.50 ± 0.06 |
Islet group | 0.34 ± 0.06 | 0.74 ± 0.11 | 0.81 ± 0.13 |
- Citation: Tang TH, Li CL, Li X, Jiang FQ, Zhang YK, Ren HQ, Su SS, Jiang GS. Immune tolerance in pancreatic islet xenotransplantation. World J Gastroenterol 2004; 10(10): 1457-1461
- URL: https://www.wjgnet.com/1007-9327/full/v10/i10/1457.htm
- DOI: https://dx.doi.org/10.3748/wjg.v10.i10.1457