Determination of lipid peroxide and superoxide dismutase in blood and tissue of patients with gastrointestinal cancer

doi:10.3748/wjg.v6.iSuppl3.94

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 15, 2000; 6(Suppl3): 94-94
Published online Sep 15, 2000. doi: 10.3748/wjg.v6.iSuppl3.94

Determination of lipid peroxide and superoxide dismutase in blood and tissue of patients with gastrointestinal cancer

Tian-Xing Zhou, Jian-Sheng Li, Lu-Wei Xing, Shu-Heng You

Tian-Xing Zhou, Jian-Sheng Li, Department of Gastroenterology, the First affiliated Hospital, Henan Medical University, Zhengzhou 450052, Henan Province, China

Lu-Wei Xing, Shu-Heng You, Department of Biochemistry, Henan Medical University, Zhengzhou 450052, Henan Province, China

Author contributions: All authors contributed equally to the work.

Correspondence to: Dr. Tian-Xing Zhou, Department of Gastroenterology, the First Affiliated Hospital, Henan Medical University, Zhengzhou 450052, Henan Province, China.

Telephone: 371-6977356

Received: May 8, 1999
Revised: January 20, 2000
Accepted: July 10, 2000
Published online: September 15, 2000

Abstract

AIM: To study the relationship between the lipid peroxide (LPO) and superoxide dismutase (SOD) and the pathogenesis of gastrointestinal cancers.

METHODS: We investigated the SOD activity and LPO levels in blood and mucosa of patients with esophageal (EC), gastric (GC) and colorectal cancer (CC), gastric ulcer (GU) and compared with normal esophagus (NE), stomach (NS) and colon (NC). respectively, 287 patients who underwent endoscopy were studied. SOD activity of the tissue and blood was determined using SUN’s adrenaline auto oxidation method. LPO levels were determined according to YU’s method.

RESULTS: The SOD activity and LPO level in blood and mucosa are shown in the Table 1 (x^-± s_x-).

CONCLUSION: SOD activity of the tissue is significantly decreased in EC. GC and CC. LPO levels were significantly higher than those of corresponding normal tissue. These results suggest that mucosal SOD and LPO levels are closely related to the pathogenesis of the gastrointestinal cancers.

Key Words: Lipid peroxides; Superoxide dismutase; Free radical; Stomach neoplasms; Esophageal neoplasms; Colorectal neoplasms

Citation: Zhou TX, Li JS, Xing LW, You SH. Determination of lipid peroxide and superoxide dismutase in blood and tissue of patients with gastrointestinal cancer. World J Gastroenterol 2000; 6(Suppl3): 94-94
URL: https://www.wjgnet.com/1007-9327/full/v6/iSuppl3/94.htm
DOI: https://dx.doi.org/10.3748/wjg.v6.iSuppl3.94

Footnotes

E- Editor: Zhang FF