Published online Sep 15, 2000. doi: 10.3748/wjg.v6.iSuppl3.77
Revised: January 10, 2000
Accepted: July 10, 2000
Published online: September 15, 2000
AIM: To study the expression of telomerase activity in malignant esophageal neoplasms and normal human esophageal epithelia.
METHODS: Telomerase activity was assayed by the telomere repeat amplification protocol (TRAP) method. All the neoplasms and epithelia of esophagus were confirmed by routine pathological diagnosis.
RESULTS: Telomerase activity was assayed in 18 normal esophageal epithelial tissues and in 35 malignant neoplasms of esophagus, including 27 cases of esophageal carcinoma and 8 cases of cardiac carcinoma. Telomerase activity was detected in most of malignant neoplasms of esophagus (91.4%, 32/35) and in all the normal esophageal epithelial tissues except one (18/19).
CONCLUSION: The results suggest that in addition to contributing to proliferation of immortal blast cells and neoplastic cells, telomerase activity may also play a similar role in regeneration of normal epithelia of human esophagus. The potential use of telomerase activity as a diagnostic marker in human esophageal neoplasm might not be suitable.
- Citation: Yang SM, Wang TJ, Li BY, Wu YH, Ye ZS. Detection of telomerase activity in malignant neoplasms and nonmalignant epithelial tissues of human esophagus. World J Gastroenterol 2000; 6(Suppl3): 77-77
- URL: https://www.wjgnet.com/1007-9327/full/v6/iSuppl3/77.htm
- DOI: https://dx.doi.org/10.3748/wjg.v6.iSuppl3.77
E- Editor: Zhang FF