Effects of Weitongling decoction on gastric mucosal blood flow and models of Spleen deficiency syndrome in rats

doi:10.3748/wjg.v6.iSuppl3.75

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 15, 2000; 6(Suppl3): 75-75
Published online Sep 15, 2000. doi: 10.3748/wjg.v6.iSuppl3.75

Effects of Weitongling decoction on gastric mucosal blood flow and models of Spleen deficiency syndrome in rats

Liang-Yuan Feng, Shun-Qin Yan, Xiang-Tao Chen

Liang-Yuan Feng, Shun-Qin Yan, Xiang-Tao Chen, Anhui College of TCM, Hefei 230038, Anhui Province, China

Author contributions: All authors contributed equally to the work.

Supported by The Natural Scientific Foundation of Educational bureau of Anhui Province, No. 97JLT29

Correspondence to: Dr. Liang-Yuan Feng, Professor, Anhui College of TCM, Hefei 230038, Anhui Province, China

Telephone: 551-2815912

Received: October 9, 1999
Revised: January 10, 2000
Accepted: April 28, 2000
Published online: September 15, 2000

Abstract

AIM: To study the protective effects of Weitongling decoction (WTL) on gastric mucosa.

METHODS: Rats with gastric lesion induced by dehydrated alcohol were used to observe the gastric mucosal blood flow (GMBF), rats with spleen deficiency syndrome induced by reserpine were applied to investigate the D-xylose absorption rate, the Alcian blue binding properties of gastric wall, the gastric acid secretion and the activity of pepsin.

RESULTS: Remarkable increases in GMBF (19.5 ± 3.5 mL/min, 20.4 ± 3.3 mL/min respectively in large dose group and small dose group, P < 0.01), in Alcian blue binding properties of gastric wall (2.497 ± 0.138 mg, 2.223 ± 0.186 mg respectively in large dose group and small dose group, P < 0.05) and in D-xylose absorption rate (1.287 ± 0.043, 1.294 ± 0.019 respectively in large dose group and small dose group, P < 0.05) were found after administrations of WTL, while no significant alteration in gastric secretion was shown and in vitro WTL did not neutralize gastric acid.

CONCLUSION: WTL can improve the Spleen deficiency syndrome, strengthen the gastric mucosal barrier, and thus protect gastric mucosa against injury agents.

Key Words: Gastric mucosa; Blood flow velocity; Spleen deficiency; Weitongling; Gastric acid; Rats

Citation: Feng LY, Yan SQ, Chen XT. Effects of Weitongling decoction on gastric mucosal blood flow and models of Spleen deficiency syndrome in rats. World J Gastroenterol 2000; 6(Suppl3): 75-75
URL: https://www.wjgnet.com/1007-9327/full/v6/iSuppl3/75.htm
DOI: https://dx.doi.org/10.3748/wjg.v6.iSuppl3.75

Footnotes

E- Editor: Zhang FF