Proliferating ability of transitional mucosa adjacent to rectal carcinoma and its clinical significance in sphincter preserving operations

doi:10.3748/wjg.v6.iSuppl3.73

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Sep 15, 2000 (publication date) through Dec 26, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 15, 2000; 6(Suppl3): 73-73
Published online Sep 15, 2000. doi: 10.3748/wjg.v6.iSuppl3.73

Proliferating ability of transitional mucosa adjacent to rectal carcinoma and its clinical significance in sphincter preserving operations

Qi Su, Yi Zhao, Cun-Sheng Chen, En-Qing Liu, Yong Feng, Wei Wang, Guan-Qun Li

Qi Su, Yi Zhao, Cun-Sheng Chen, En-Qing Liu, Yong Feng, Department of Surgery, The 2^nd Clinical College, China Medical University, Shenyang 110003, Liaoning Province, China

Wei Wang, Guan-Qun Li, Department of Pathology, The 2^nd Clinical College, China Medical University, Shenyang 110003, Liaoning Province, China

Author contributions: All authors contributed equally to the work.

Supported by The Natural Scientific Foundation of Liaoning Province, No. 972255

Correspondence to: Dr. Qi Su, Department of Surgery, The 2^nd Affiliated Hospital China Medical University, Shenyang 110003, Liaoning Province, China

Telephone: 24-23893501-384 Fax: 24-23892617

Received: May 11, 1999
Revised: March 12, 2000
Accepted: July 10, 2000
Published online: September 15, 2000

Abstract

AIM: To study the biopathologic characteristics of the transitional mucosa (TM) adjacent to rectal carcinoma and the resecting length of bowel.

METHODS: Immunohistochemical and mucin histochemical methods were used in 81 cases to observe the expression of PCNA and the changing regulations of TM adjacent to rectal carcinoma.

RESULTS: The PCNA expression rate was the highest in cancer and gradually decreased in atypical dysplasia, TM and normal mucosa (P < 0.01). The range of TM adjacent to the mucinous adenocarcinoma was more extensive than that to the papilla adenocarcinoma and the tubular adenocarcinoma (P < 0.01). The range of TM adjacent to the rectal carcinoma in Dukes C stage was more extensive than that in stage A, B (P < 0.01, P < 0.05).

CONCLUSION: The TM of rectal carcinoma possesses certain potential of malignancy. The range of TM adjacent to rectal carcinoma is closely related to the pathological type and advancement of rectal carcinoma.

Key Words: Rectal neoplasms/surgery; Intestinal mucosa; Anus; Immunohistochemistry

Citation: Su Q, Zhao Y, Chen CS, Liu EQ, Feng Y, Wang W, Li GQ. Proliferating ability of transitional mucosa adjacent to rectal carcinoma and its clinical significance in sphincter preserving operations. World J Gastroenterol 2000; 6(Suppl3): 73-73
URL: https://www.wjgnet.com/1007-9327/full/v6/iSuppl3/73.htm
DOI: https://dx.doi.org/10.3748/wjg.v6.iSuppl3.73

Footnotes

E- Editor: Zhang FF