Abstracts Open Access
Copyright ©The Author(s) 2000. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 15, 2000; 6(Suppl3): 66-66
Published online Sep 15, 2000. doi: 10.3748/wjg.v6.iSuppl3.66
Role of Chinese herbal medicines in a rat model of chronic colitis
Xiao-Lan Tian, Yu-Ling Li, Department of Digestive Diseases, People’s Hospital of Hainan Province, Haikou 570311, Hainan Province, China
Marisabel Mourelle, Francisco Guarner, Juan R Malagelada, Digestive System Research Unit, Hospital General Vall d’Hebron, 08035 Barcelona, Spain
Author contributions: All authors contributed equally to the work.
Correspondence to: Dr. Xiao-Lan Tian, Department of Digestive Diseases, People’s Hospital of Hainan Province, Haikou 570311, Hainan Province, China. Xiaolan@public.hk.hi.cn
Telephone: 898-8642100
Received: April 3, 2000
Revised: May 10, 2000
Accepted: June 18, 2000
Published online: September 15, 2000

Abstract

AIM: To investigate a mixture of traditional Chinese medicine (TCM) in the prevention of chronic colitis in rats.

METHODS: Sixty rats were divided into 3 groups. Colitis was in duced by trinitrobenzene-sulfonic acid (TNB). On day 10, all the survived rats were killed, the mortality and intestinal obstruction rate were calculated, the colonic lesion score was assessed and collagenase activity and collagen concentration were measured.

RESULTS: The survival rate was much lower and intestinal obstruction rate much higher in TNB than those in TCM, they were 53% and 81% vs 80% and 24% (P < 0.05 and P < 0.01, respectively). There were also significant differences in colonic stricture score and colonic weight between TNB and TCM groups (1.75 ± 1.2 vs 0.22 ± 0.67 and 0.57 ± 0.36 vs 0.31 ± 0.10, P < 0.01 and P < 0.05, respectively). No hydroxyproline and collagenase activity differences were found between the two groups.

CONCLUSION: This mixture of TCM prevents the formation of intestinal stricture, increases the survival rate and decreases intestinal obstruction rate in a rat model of chronic colitis.

Key Words: Trinitrobenzenesulfonic; Colitis/drug therapy (TCD); Rats; drugs, Chinese herbal; Blood stasis removing drugs; Models



Footnotes

E- Editor: Zhang FF

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