Detection of telomerase activity and cytology in diagnosis of cardiac cancer

doi:10.3748/wjg.v6.iSuppl3.46

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Sep 15, 2000 (publication date) through Nov 20, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 15, 2000; 6(Suppl3): 46-46
Published online Sep 15, 2000. doi: 10.3748/wjg.v6.iSuppl3.46

Detection of telomerase activity and cytology in diagnosis of cardiac cancer

Qiang Wang, Qing-Ming Wu, Sheng-Bao Li

Qiang Wang, Qing-Ming Wu, Sheng-Bao Li, Department of Gastroenterology of Taihe Affiliated Hospital, Yunyang Medical College, Shiyan 442000, Hubei Province, China

Author contributions: All authors contributed equally to the work.

Correspondence to: Dr. Qiang Wang, Department of Gastroenterology of Taihe Affiliated Hospital, Yunyang Medical College, No. 29 South Remin Road, Shiyan 442000, Hubei Province, China

Telephone: 719-8801431

Received: May 18, 2000
Revised: June 24, 2000
Accepted: July 10, 2000
Published online: September 15, 2000

Abstract

AIM: To investigate the diagnostic significance of cytology and telomerase activity in the exfoliated cells of cardia obtained from endoscopic brushing in the cardiac cancer.

METHODS: The techniques of the qualitative TRAP-silver staining and quantitative TRAP-PCR-ELISA were employed to detect telomerase activity in the exfoliated cells of cardia obtained from endoscopic brushing in 72 cases with cardial lesions, cytological diagnosis was made at the same time.

RESULTS: Telomerase activity with cardiac cancer group (1.521 ± 0.192) was significantly higher than that with cardinality group (0.065 ± 0.014). Positive rate of telomerase activity detected in cardiac cancer group (88.89%) was significantly higher than that with cardialitis group (11.11%), the former was significantly higer than cytological examination (77.78%). The diagnostic rate of cardiac cancer reached 93.33% if telomerase activity and cytology were examined at the same time.

CONCLUSION: Cytology and telomerase activity in the exfoliated cardiac cells may be an effective and sensitive methods in the diagnosis of cardiac cancer. This research can be a basis for the mass screening of cardiac cancer. the National Natural Science Foundation of China, No. 39900177.

Key Words: Stomach neoplasms/diagnosis; Cardiac/cytology; Telomerase; Exfoliated cell; Gastroscopy; Mass screening

Citation: Wang Q, Wu QM, Li SB. Detection of telomerase activity and cytology in diagnosis of cardiac cancer. World J Gastroenterol 2000; 6(Suppl3): 46-46
URL: https://www.wjgnet.com/1007-9327/full/v6/iSuppl3/46.htm
DOI: https://dx.doi.org/10.3748/wjg.v6.iSuppl3.46

Footnotes

E- Editor: Hu S