Effects of tachyplesin on the morphology and ultrastructure of the human gastriccarcinoma cell line BGC-823

doi:10.3748/wjg.v6.iSuppl3.111

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 15, 2000; 6(Suppl3): 111-111
Published online Sep 15, 2000. doi: 10.3748/wjg.v6.iSuppl3.111

Effects of tachyplesin on the morphology and ultrastructure of the human gastriccarcinoma cell line BGC-823

Qi-Fu Li, Gao-Liang Quyang, Chang-You Li, Shui Gen Hong

Qi-Fu Li, Gao-Liang Quyang, Chang-You Li, Shui Gen Hong, Laboratory of Cell Biology, College of Life Science, Xiamen University, Xiamen 361005, Fujian Province, China

Author contributions: All authors contributed equally to the work.

Correspondence to: Qi-Fu Li, Laboratory of Cell Biology, College of Life Science, Xiamen University, Xiamen 361005, Fujian Province, China

Received: May 6, 2000
Revised: June 24, 2000
Accepted: July 10, 2000
Published online: September 15, 2000

Abstract

AIM: To investigate the morphological and ultrastructural changes in the human gastric carcinoma cell line BGC-823 after being treated with tachyplesin.

METHODS: Tachyplesin was isolated from acid extracts of Chinese horseshoe crab (Tachypleus tridentatus) hemocytes. BGC-823 cells and the cells treated with 2.0 μg/mL tachyplesin were examined respectively with light microscope, scanning and transmission electron microscope.

RESULTS: BGC-823 cells had undergone restorative morphological and ultrastructural changes after being treated with 2.0 μg/mL tachyplesin. The cells tended to be flat and spread, and their volume enlarged, nucleo-cytoplasmic ratio decreased, the shape of nucleus became relatively regular, the number and volume of nuleous decreased, heterchromatin decreased while euchromatin increased, the number of mitochondria increased with their structure relatively consistent, Golgi apparatus turned to be typical, rough endoplasmic reticulum increased, polyribosome decreased, microvilli and filopodia reduced while lamellipodia increased.

CONCLUSION: Tachyplesin could change the malignant morphological and ultrastructural characteristics of human gastric carcinoma cells effectively and had certain effects on inducing differentiation of human gastric carcinoma cells.

Key Words: Horseshoe crabs; Stomach neoplasms; Hemocytes/ultrastructure; Heterochromatin; Microscopy, electron; Tachyplesin

Citation: Li QF, Quyang GL, Li CY, Hong SG. Effects of tachyplesin on the morphology and ultrastructure of the human gastriccarcinoma cell line BGC-823. World J Gastroenterol 2000; 6(Suppl3): 111-111
URL: https://www.wjgnet.com/1007-9327/full/v6/iSuppl3/111.htm
DOI: https://dx.doi.org/10.3748/wjg.v6.iSuppl3.111

Footnotes

E- Editor: Hu S