Effects of electro-acupuncture on 5-HT, NOS and the gastric mucosa of stress rats

doi:10.3748/wjg.v3.i3.179

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Sep 15, 1997 (publication date) through Dec 22, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 15, 1997; 3(3): 179-179
Published online Sep 15, 1997. doi: 10.3748/wjg.v3.i3.179

Effects of electro-acupuncture on 5-HT, NOS and the gastric mucosa of stress rats

Shun-Li Zhu, Guan-Sun Xu, Zhen-Jiu Wang, Quan-Zhu Chen, Jie Jiao

Shun-Li Zhu, Guan-Sun Xu, Zhen-Jiu Wang, Quan-Zhu Chen, Jie Jiao, Institute of Acupuncture and Meridians, Anhui College of Traditional Chinese Medicine, Hefei 230038, Anhui Province, China

Author contributions: All authors contributed equally to the work.

Correspondence to: Dr. Shun-Li Zhu, Institute of Acupuncture and Meridians, Anhui College of Traditional Chinese Medicine, Hefei 230038, Anhui Province, China

Received: October 31, 1996
Revised: December 22, 1996
Accepted: January 30, 1997
Published online: September 15, 1997

Abstract

AIM: To study the effects of electro-acupuncture (EA) on 5-hydroxytryptophan (5-HT) levels, nitrous oxide (NOS) levels, nitric oxide (NO) levels, and the gastric mucosa in stress rats.

METHODS: The changes of 5-HT and NOS were measured in the gastric mucosa, and NO and 5-HT were measured in the serum by biochemical methods. The gastric mucosa was examined pathohistologically in the stress rats with gastric mucosa damage after EA. The changes before and after stress by EA were compared.

RESULTS: EA decreased the gastric mucosa damage index in the stress rats (2.71 ± 0.40 to 1.86 ± 0.69, P < 0.01). EA normalized NOS level in gastric mucosa to the control group. The changes before stress by EA was more obvious than that after stress. EA lowered the 5-HT levels in the gastric mucosa (μg/g wet weight, 6.91 ± 3.08 to 4.51 ± 1.62, P < 0.01). EA recovered the NO level in serum of the stress rats (μmol/L, 5.78 ± 1.49 to 7.91 ± 1.11, P < 0.05), and increased the levels of 5-HT and 5-hydroxyindoleacetic acid (5-HIAA) in serum continuously.

CONCLUSION: EA stimulation normalizes the NOS and NO levels in the gastric mucosa of stress rats. EA also lowers the high 5-HT levels and induces NO release.

Key Words: Electroacupuncture; Serotonin/acu-moxibustion effects; Aminoacid oxidoreductases/acu-moxibustion effects; Gastric mucosa/Acu-moxibustion effects

Citation: Zhu SL, Xu GS, Wang ZJ, Chen QZ, Jiao J. Effects of electro-acupuncture on 5-HT, NOS and the gastric mucosa of stress rats. World J Gastroenterol 1997; 3(3): 179-179
URL: https://www.wjgnet.com/1007-9327/full/v3/i3/179.htm
DOI: https://dx.doi.org/10.3748/wjg.v3.i3.179

Footnotes

Original title: China National Journal of New Gastroenterology (1995-1997) renamed World Journal of Gastroenterology (1998-)

S- Editor: Filipodia L- Editor: Jennifer E- Editor: Hu S