Adenosine 2A receptor contributes to the facilitation of post-infectious irritable bowel syndrome by γδ T cells via the PKA/CREB/NF-κB signaling pathway

Figure 6 The inflammatory response alteration after adenosine 2A receptor knockdown. A: The altered level of adenosine 2A receptor (A2AR) expression after A2AR-shRNA transfection or γδ T cell reinfusion in post-infectious irritable bowel syndrome (PI-IBS) mice was assessed. The results were obtained from three times of independently repeated experiments; B: The relative ratio of the intestinal cytokine level in PI-IBS mice (n = 6, per group); C: The degree of TJ (tight junction protein) protein expression in PI-IBS mice (n = 6, per group). ^aP < 0.05, ^bP < 0.01, ^eP < 0.001 vs the PI-IBS group; ^cP < 0.05, ^dP < 0.01, ^fP < 0.001 vs the IBS + γδ T group.