Review
Copyright ©The Author(s) 2023.
World J Gastroenterol. Feb 14, 2023; 29(6): 997-1010
Published online Feb 14, 2023. doi: 10.3748/wjg.v29.i6.997
Figure 2
Figure 2 Overview of RAGE-dependent intracellular signaling. RAGE binding triggers myriad mechanisms that support tumor proliferation and survival, invasion, and metastasis. AGE: Advanced glycation end product; AP-1: Activator protein-1; CREB: cyclic-AMP response element binding; ERK: Extracellular signal-regulated kinase; HMGB1: High mobility group box 1; JAK: Janus kinase; JNK: c-Jun n-terminal kinase; NF-ҡB: Nuclear factor-kappa B; PAMP: Pathogen-associated molecular patterns; RAGE: Receptor for advanced glycation end products; SAPK: Stress-activated protein kinase; STAT: Signal transducer and activator of transcription; TIRAP: Toll-interleukin 1 receptor domain-containing adaptor protein.