Review
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 14, 2023; 29(6): 997-1010
Published online Feb 14, 2023. doi: 10.3748/wjg.v29.i6.997
Contributions of the receptor for advanced glycation end products axis activation in gastric cancer
Armando Rojas, Cristian Lindner, Iván Schneider, Ileana González, Miguel Angel Morales
Armando Rojas, Ileana González, Biomedical Research Laboratories, Medicine Faculty, Catholic University of Maule, Talca 34600000, Chile
Cristian Lindner, Iván Schneider, Medicine Faculty, Catholic University of Maule, Talca 34600000, Chile
Miguel Angel Morales, Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, University of Chile, Santiago 8320000, Chile
Author contributions: All authors contributed to the original ideas and writing of this paper; Rojas A designed the report and wrote the paper; Lindner C created the artwork and performed data acquisition, drafting and revision of the manuscript; Schneider I, González I and Morales MA contributed to the data acquisition, drafting and revision of the manuscript.
Conflict-of-interest statement: All the authors report having no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Armando Rojas, PhD, Full Professor, Senior Researcher, Biomedical Research Laboratories, Medicine Faculty, Catholic University of Maule, 3605 San Miguel Ave., Talca 34600000, Chile. arojasr@ucm.cl
Received: October 21, 2022
Peer-review started: October 21, 2022
First decision: November 14, 2022
Revised: November 26, 2022
Accepted: January 11, 2023
Article in press: January 11, 2023
Published online: February 14, 2023
Processing time: 111 Days and 13.5 Hours
Core Tip

Core Tip: During the last two decades, new evidence supported by basic and clinical research has supported the role of the receptor for advanced glycation end products (RAGE) axis as a crucial actor in gastric carcinogenesis. We herein discuss how RAGE overexpression and RAGE activation-mediated signaling mechanisms are the main contributions of the RAGE axis to tumor development, migration, and metastasis in gastric cancer.