Recent advances in multidisciplinary therapy for adenocarcinoma of the esophagus and esophagogastric junction

Figure 1 Siewert classification of adenocarcinoma of the esophagogastric junction and recommended surgical options[3,4,28,29]. The tumors that centered 1-5 cm above esophagogastric junction (EGJ) are defined as Siewert type I, transthoracic esophagectomy is recommended. the tumors centered from 1 cm above to 2 cm below the EGJ are Siewert type II. For Siewert type II tumor with esophageal invasion ≥ 3 cm, Ivor-Lewis esophagectomy with upper/middle mediastinal lymphadenectomy is propriate surgical option; for esophageal invasion < 3 cm, extended proximal transhiatal gastrectomy or extended total trashiatal gastrectomy with lower mediastinal lymphadenectomy are recommended according to whether gastric invasion exceeded 1/3 of the stomach. The tumors that centered 2-5 cm below EGJ are defined as Siewert type III and extended total gastrectomy is the optimal surgical option. EGJ: Esophagogastric junction.