Development and validation of a prediction model for moderately severe and severe acute pancreatitis in pregnancy

Table 2 Demographic and clinical characteristics of patients in training group

	Training set			Test set
Parameters	MAIP (96)	MSIP (38)	P value	MAIP (40)	MSIP (16)	P value
Age	27.16 ± 5.46	30.13 ± 6.09	0.007	28.70 ± 4.60	27.88 ± 3.79	0.528
Etiology			0.620			0.804
Hypertriglyceridemia	32 (33.3)	18 (47.4)		18 (45.0)	7 (43.8)
Gallstone	36 (37.5)	13 (34.2)		9 (22.5)	5 (31.2)
Other	28 (29.2)	7 (18.4)		13 (32.5)	4 (25.0)
Comorbidity
Hypertension	0 (0.0)	2 (5.3)	0.079	0 (0.0)	0 (0.0)	-
Diabetes	6 (6.3)	9 (23.7)	0.012	2 (5.0)	4 (25.0)	0.049
Fatty liver disease	20 (20.8)	11 (28.9)	0.437	12 (30.0)	5 (31.2)	1.000
Smoking	1 (1.0)	2 (5.3)	0.400	2 (5.0)	0 (0.0)	0.909
Drinking	3 (3.1)	1 (2.6)	1.000	1 (2.5)	0 (0.0)	1.000
Trimester of pregnancy on admission
Early (1–12 wk)	6 (6.3)	2 (5.3)		3 (7.5)	1 (6.3)
Mid (12–24 wk)	22 (22.9)	8 (21.1)		9 (22.5)	2 (12.5)
Late (24–40 wk)	68 (70.8)	28 (73.7)		28 (70.0)	13 (81.3)
Gestational weeks on admission	27.53 ± 7.52	29.74 ± 6.34	0.113	29.25 ± 8.15	26.56 ± 7.01	0.252
Onset to admission (d)	1.63 ± 1.35	2.12 ± 1.87	0.090	1.50 ± 1.44	1.29 ± 0.63	0.586
Blood infection	0 (0.0)	6 (15.8)	< 0.001	0 (0.0)	2 (12.5)	0.139
LOS	6.99 ± 4.43	23.11 ± 48.52	< 0.001	7.90 ± 3.63	18.25 ± 12.96	0.001
Fetal death	1 (1.0)	9 (23.7)	< 0.001	2 (5.0)	4 (25.0)	0.049
Maternal hospital mortality	0 (0.0)	1 (2.6)	0.284	0 (0.0)	0 (0.0)	-
Hematocrit	0.33 ± 0.05	0.32 ± 0.06	0.734	0.33 ± 0.05	0.30 ± 0.05	0.040
Platelet	169.57 ± 56.91	141.97 ± 61.66	0.015	152.07 ± 48.61	160.80 ± 73.24	0.604
WBC	12.89 ± 4.82	13.94 ± 4.10	0.239	11.87 ± 4.42	14.64 ± 4.37	0.038
Neutrophils	11.19 ± 4.52	12.34 ± 3.83	0.166	10.09 ± 4.06	12.85 ± 4.39	0.029
Lymphocytes	1.00 ± 0.38	0.91 ± 0.49	0.246	1.01 ± 0.44	0.81 ± 0.41	0.129
Monocytes	0.55 ± 0.23	0.48 ± 0.29	0.147	0.56 ± 0.25	0.47 ± 0.22	0.249
Alanine aminotransferase	55.20 ± 82.18	22.91 ± 44.14	0.024	40.73 ± 69.69	11.62 ± 6.40	0.103
Albumin	34.44 ± 3.72	29.68 ± 5.49	< 0.001	33.71 ± 3.62	28.62 ± 4.41	< 0.001
Creatinine	42.90 ± 9.16	86.27 ± 117.45	< 0.001	41.78 ± 9.69	51.17 ± 22.10	0.030
Aspartate aminotransferase	54.45 ± 69.25	40.67 ± 58.67	0.281	43.33 ± 63.66	21.77 ± 10.97	0.186
Alkaline phosphatase	114.05 ± 51.61	100.65 ± 37.29	0.148	112.39 ± 54.23	82.86 ± 33.70	0.048
creatine kinase	36.46 ± 26.55	129.89 ± 242.89	< 0.001	35.58 ± 24.47	117.98 ± 124.10	< 0.001
LDH	183.85 ± 63.85	356.97 ± 234.19	< 0.001	188.86 ± 72.86	323.09 ± 134.59	< 0.001
Triglyceride	5.44 ± 6.86	12.62 ± 8.01	< 0.001	6.91 ± 6.33	12.46 ± 5.66	0.004
cholesterol	6.79 ± 4.43	12.19 ± 6.18	< 0.001	8.68 ± 7.70	14.24 ± 7.63	0.018
High density lipoprotein	1.42 ± 0.49	1.18 ± 0.39	0.007	1.34 ± 0.43	1.12 ± 0.40	0.078
Low density lipoprotein	2.27 ± 1.18	2.00 ± 1.58	0.282	2.17 ± 1.35	1.78 ± 1.67	0.364
Sodium	135.91 ± 3.19	133.94 ± 5.71	0.012	134.93 ± 5.01	132.68 ± 4.72	0.129
Potassium	3.76 ± 0.30	3.88 ± 0.47	0.075	3.78 ± 0.44	3.71 ± 0.45	0.588
Chlorine	102.63 ± 4.22	103.14 ± 6.80	0.597	101.06 ± 4.85	100.78 ± 5.14	0.849

MAIP: Mild acute pancreatitis in pregnancy; MSIP: Moderately severe and severe acute pancreatitis in pregnancy; LOS: Length of hospital stay; WBC: White blood cell; LDH: Lactate dehydrogenase.